Wang Hongmei, Jin Chenwang, Yuan Kai, Shakir Tahir Mehmood, Mao Cuiping, Niu Xuan, Niu Chen, Guo Liping, Zhang Ming
Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
School of Life Science and Technology, Xidian University Xi'an, China ; Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an, China.
Front Behav Neurosci. 2015 Mar 20;9:64. doi: 10.3389/fnbeh.2015.00064. eCollection 2015.
Internet gaming disorder (IGD) has been investigated by many behavioral and neuroimaging studies, for it has became one of the main behavior disorders among adolescents. However, few studies focused on the relationship between alteration of gray matter volume (GMV) and cognitive control feature in IGD adolescents.
Twenty-eight participants with IAD and twenty-eight healthy age and gender matched controls participated in the study. Brain morphology of adolescents with IGD and healthy controls was investigated using an optimized voxel-based morphometry (VBM) technique. Cognitive control performances were measured by Stroop task, and correlation analysis was performed between brain structural change and behavioral performance in IGD group.
The results showed that GMV of the bilateral anterior cingulate cortex (ACC), precuneus, supplementary motor area (SMA), superior parietal cortex, left dorsal lateral prefrontal cortex (DLPFC), left insula, and bilateral cerebellum decreased in the IGD participants compared with healthy controls. Moreover, GMV of the ACC was negatively correlated with the incongruent response errors of Stroop task in IGD group.
Our results suggest that the alteration of GMV is associated with the performance change of cognitive control in adolescents with IGD, which indicating substantial brain image effects induced by IGD.
网络成瘾障碍（IGD）已被众多行为学和神经影像学研究，因为它已成为青少年主要的行为障碍之一。然而，很少有研究关注IGD青少年的灰质体积（GMV）改变与认知控制特征之间的关系。
28名患有网络成瘾障碍（IAD）的参与者和28名年龄、性别匹配的健康对照者参与了该研究。采用优化的基于体素的形态学测量（VBM）技术研究IGD青少年和健康对照者的脑形态。通过Stroop任务测量认知控制表现，并对IGD组的脑结构变化与行为表现进行相关分析。
结果显示，与健康对照者相比，IGD参与者双侧前扣带回皮质（ACC）、楔前叶、辅助运动区（SMA）、顶上叶皮质、左侧背外侧前额叶皮质（DLPFC）、左侧岛叶和双侧小脑的GMV降低。此外，IGD组中ACC的GMV与Stroop任务的不一致反应错误呈负相关。
我们的结果表明，GMV的改变与IGD青少年认知控制的表现变化相关，这表明IGD会引起显著的脑影像效应。
