Patil Santosh, Al-Zarea Bader Kureyem, Maheshwari Sneha, Sahu Rohit
Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia.
Dental Practitioner, Jodhpur, Rajasthan, India.
J Oral Biol Craniofac Res. 2015 Jan-Apr;5(1):11-5. doi: 10.1016/j.jobcr.2014.12.005. Epub 2015 Jan 22.
Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.
42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.
The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.
Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.
口腔黏膜下纤维化（OSMF）是一种主要见于印度次大陆的高风险癌前病变。本研究的目的是比较螺旋藻和芦荟在OSMF治疗中的疗效。
42例经临床病理诊断为OSMF的受试者纳入本研究，并平均分为2组，A组（螺旋藻组）和B组（芦荟组）。A组给予500毫克螺旋藻，分2次服用，共3个月；B组给予5毫克芦荟凝胶，每天局部涂抹3次，共3个月。定期对不同临床参数进行评估，并使用卡方检验分析数据。P值<0.05被认为具有统计学意义。
A组患者在张口度和溃疡/糜烂/水疱方面有显著临床改善（p<0.05）。然而，两组在烧灼感（p = 0.06）和与病变相关的疼痛（p = 0.04）方面均无显著改善。
两种药物均使病情有所改善；然而，螺旋藻能使张口度和溃疡/糜烂/水疱等症状有显著临床改善。因此，与芦荟相比，螺旋藻在治疗OSMF方面似乎更有前景。
