Design of an osteoinductive extracellular fibronectin matrix protein for bone tissue engineering.
作者信息
Lee Sujin, Lee Dong-Sung, Choi Ilsan, Pham Le B Hang, Jang Jun-Hyeog
机构信息
Department of Biochemistry, College of Medicine, Inha University, Incheon 400-712, Korea.
Department of Biomedical Chemistry, Konkuk University, Chung-Ju 380-701, Korea.
出版信息
Int J Mol Sci. 2015 Apr 7;16(4):7672-81. doi: 10.3390/ijms16047672.
Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a significant increase in cell adhesion and osteogenic differentiation of pre-osteoblast MC3T3-E1 cells (p < 0.05).
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