用于细菌抑制的有机-无机杂化纳米颗粒：掺杂和未掺杂银/金纳米颗粒的有机-无机杂化纳米颗粒的合成与表征
Organic-inorganic hybrid nanoparticles for bacterial inhibition: synthesis and characterization of doped and undoped ONPs with Ag/Au NPs.
作者信息
Aguilar Carlos Alberto Huerta, Jiménez Adriana Berenice Pérez, Silva Antonio Romero, Kaur Navneet, Thangarasu Pandiyan, Ramos Jorge Manuel Vázquez, Singh Narinder
机构信息
Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico.
Centre for Nanoscience & Nanotechnology, Panjab University, Chandigarh, Panjab 160014, India.
出版信息
Molecules. 2015 Apr 7;20(4):6002-21. doi: 10.3390/molecules20046002.
Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi). Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was analyzed by molecular orbital and density of state (DOS) using DFT.
制备了硫辛酸有机纳米颗粒（ONPs）及其掺杂衍生物ONPs/Ag和ONPs/Au，并通过紫外可见光谱、能谱分析（EDS）和透射电子显微镜（TEM）分析对其进行了表征。测试了ONPs、ONPs/Ag和ONPs/Au对细菌菌株（金黄色葡萄球菌、蜡状芽孢杆菌、大肠杆菌和伤寒沙门氏菌）的抗菌性能。最小抑菌浓度（MIC）和细菌生长抑制试验表明，ONPs/Ag在限制细菌生长方面比其他纳米颗粒更有效，特别是对革兰氏阳性菌比对革兰氏阴性菌更有效。细菌细胞生长抑制顺序为ONPs/Ag > ONPs > ONPs/Au。通过扫描电子显微镜（SEM）分析了处理后细菌细胞膜的形态。使用密度泛函理论（DFT）通过分子轨道和态密度（DOS）分析了LA与Ag或Au形成键的性质。
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