Kaminaka Chikako, Uede Mikiko, Matsunaka Hiroshi, Furukawa Fukumi, Yamamoto Yuki
Department of Dermatology, Wakayama Medical University, Wakayama, Japan.
Department of Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan.
J Dermatol. 2015 Jun;42(6):580-7. doi: 10.1111/1346-8138.12864. Epub 2015 Apr 9.
Few clinical studies have examined the utility of bipolar fractional radiofrequency (FRF) therapy as a treatment for atrophic acne scars and active acne in people with darker skin. This study was designed to compare the safety and efficacy of bipolar FRF therapy as a treatment for atrophic acne scars and acne vulgaris. Twenty-three Japanese patients with atrophic acne scars and mild to severe acne on both cheeks were treated with a bipolar FRF system (eMatrix; Syneron, Yokneam Illit, Israel). Five treatment sessions were carried out at 1-month intervals, and the patients were followed up for 3 months after the final treatment. Assessments of scar severity and the number of acne lesions and 3-D in vivo imaging analysis were performed. Evaluations of the treatment outcomes and their effects on the patients' quality of life (QOL) were also carried out. We demonstrated that the improvement in scar volume was marked in the patients with mild scars and was at least moderate in 23 (57.5%) of the treated areas. With regard to the number of acne lesions, the treated areas exhibited significantly fewer lesions compared with the baseline at each time point (P < 0.05). The patients' assessments of the treatment outcomes and their QOL indicated that both had improved significantly by the end of the study. Furthermore, significant reductions in the patients' sebum levels, skin roughness and scar depth were observed. Bipolar FRF treatment significantly improved the atrophic acne scars and acne of Japanese patients and had minimal side-effects.
很少有临床研究检验双极分数射频（FRF）疗法治疗深色皮肤人群萎缩性痤疮瘢痕和活动性痤疮的效用。本研究旨在比较双极FRF疗法治疗萎缩性痤疮瘢痕和寻常痤疮的安全性和有效性。23名日本患者双侧脸颊有萎缩性痤疮瘢痕且患有轻至重度痤疮，接受了双极FRF系统（eMatrix；赛诺龙公司，以色列约克尼姆伊利特）治疗。每隔1个月进行5次治疗，最后一次治疗后对患者随访3个月。进行了瘢痕严重程度、痤疮皮损数量评估及三维活体成像分析。还对治疗效果及其对患者生活质量（QOL）的影响进行了评估。我们证明，轻度瘢痕患者的瘢痕体积改善明显，且23个（57.5%）治疗区域至少有中度改善。关于痤疮皮损数量，各时间点治疗区域的皮损数量与基线相比均显著减少（P<0.05）。患者对治疗效果及其生活质量的评估表明，到研究结束时二者均有显著改善。此外，观察到患者的皮脂水平、皮肤粗糙度和瘢痕深度显著降低。双极FRF治疗显著改善了日本患者的萎缩性痤疮瘢痕和痤疮，且副作用极小。
