Ramos-Torrecillas Javier, De Luna-Bertos Elvira, García-Martínez Olga, Ruiz Concepción
the Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain.
the Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain; email:
Wounds. 2014 Jul;26(7):207-13.
Many elements are involved in the regenerative processof injured tissues, such as cytokines and growth factors. Growth factors contained in platelets represent an important physiological mixture of factors that may be involved in the healing process.
A literature review on the role played by certain biomolecules, such as growth factors and platelet-rich plasma (PRP), in the healing of different tissues and on their therapeutic use to promote this process was undertaken.
In this review, the authors found a great number of studies that showed the effect of growth factors and PRP in the regeneration of different tissues. Platelet-rich plasma is a natural source of growth factors and this has been successfully used in different clinical situations such as dentistry, plastic surgery, trauma and orthopedics, ocular surgery, gastroenterology, or skin ulcers. However, standardized protocol for its preparation and applicationhas yet to be established.
The authors recommend further research is required to establish the exact role of PRP in the treatment of tissue regeneration and to develop a standardized protocol for its use.
许多元素参与了受损组织的再生过程，如细胞因子和生长因子。血小板中含有的生长因子是可能参与愈合过程的重要生理因子混合物。
对某些生物分子，如生长因子和富血小板血浆（PRP），在不同组织愈合中的作用及其促进该过程的治疗用途进行了文献综述。
在本综述中，作者发现大量研究表明生长因子和PRP在不同组织再生中的作用。富血小板血浆是生长因子的天然来源，已成功应用于不同临床情况，如牙科、整形手术、创伤与骨科、眼科手术、胃肠病学或皮肤溃疡。然而，其制备和应用的标准化方案尚未确立。
作者建议需要进一步研究以确定PRP在组织再生治疗中的确切作用，并制定其使用的标准化方案。
