Lv Xiuhe, Wang Chunhui, Xie Yan, Yan Zhaoping
Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
PLoS One. 2015 Apr 9;10(4):e0123832. doi: 10.1371/journal.pone.0123832. eCollection 2015.
Magnifying endoscopy with narrow-band imaging (ME-NBI) is a novel, image-enhanced endoscopic technique for differentiating gastrointestinal neoplasms and potentially enabling pathological diagnosis.
The aim of this analysis was to assess the diagnostic performance of ME-NBI for gastric neoplasms.
We performed a systematic search of the PubMed, EMbase, Web of Science, and Cochrane Library databases for relevant studies. Meta-DiSc (version 1.4) and STATA (version 11.0) software were used for the data analysis. Random effects models were used to assess diagnostic efficacy. Heterogeneity was tested by the Q statistic and I2 statistic. Meta-regression was used to analyze the sources of heterogeneity.
A total of 10 studies, with 2151 lesions, were included. The pooled characteristics of these studies were as follows: sensitivity 0.85 (95% confidence interval [CI]: 0.81-0.89), specificity 0.96 (95% confidence interval [CI]: 0.95-0.97), and area under the curve (AUC) 0.9647. In the subgroup analysis, which compared the diagnostic efficacy of ME-NBI and white light imaging (WLI), the pooled sensitivity and specificity of ME-NBI were 0.87 (95% CI: 0.80-0.92) and 0.93 (95% CI: 0.90-0.95), respectively, and the area under the curve (AUC) was 0.9556. In contrast, the pooled sensitivity and specificity of WLI were 0.61 (95% CI: 0.53-0.69) and 0.65 (95% CI: 0.60-0.69), respectively, and the area under the curve (AUC) was 0.6772.
ME-NBI presents a high diagnostic value for gastric neoplasms and has a high specificity.
窄带成像放大内镜检查（ME-NBI）是一种用于鉴别胃肠道肿瘤并可能实现病理诊断的新型图像增强内镜技术。
本分析旨在评估ME-NBI对胃肿瘤的诊断性能。
我们对PubMed、EMbase、Web of Science和Cochrane图书馆数据库进行了系统检索以查找相关研究。使用Meta-DiSc（1.4版）和STATA（11.0版）软件进行数据分析。采用随机效应模型评估诊断效能。通过Q统计量和I²统计量检验异质性。使用Meta回归分析异质性来源。
共纳入10项研究，涉及2151个病变。这些研究的合并特征如下：敏感性0.85（95%置信区间[CI]：0.81-0.89），特异性0.96（95%置信区间[CI]：0.95-0.97），曲线下面积（AUC）0.9647。在比较ME-NBI与白光成像（WLI）诊断效能的亚组分析中，ME-NBI的合并敏感性和特异性分别为0.87（95%CI：0.80-0.92）和0.93（95%CI：0.90-0.95），曲线下面积（AUC）为0.9556。相比之下，WLI的合并敏感性和特异性分别为0.61（95%CI：0.53-0.69）和0.65（95%CI：0.60-0.69），曲线下面积（AUC）为0.6772。
ME-NBI对胃肿瘤具有较高的诊断价值且特异性较高。
