Kubota S, Sato S, Nakano T, Morita S, Tunemoto H, Ando K, Sekiya T, Sugishita T
Dept. of Hospital, National Institute of Radiational Sciences.
Gan No Rinsho. 1989 Oct;35(13):1572-5.
The aim of the study is to investigate the relationship between DNA histogram and radiosensitivity on tumor specimens taken directly from patients. Flow cytometric DNA content analysis with PI (Propidium iodide) was performed on specimens of cervical carcinoma. Radiosensitivities of respective tumors were determined on biopsy specimens that were taken 3 weeks after the start of radiotherapy. Five parameters (over 4C, %G2M, %S, PI, DI) were calculated from DNA Histogram. Among these parameters over 4C, %G2M and PI correlated well to radiosensitivity.
本研究的目的是调查直接取自患者的肿瘤标本的DNA直方图与放射敏感性之间的关系。对宫颈癌标本进行了用碘化丙啶（PI）的流式细胞术DNA含量分析。在放疗开始3周后采集的活检标本上测定各肿瘤的放射敏感性。从DNA直方图计算出五个参数（超4C、G2M%、S%、PI、DI）。在这些参数中，超4C、G2M%和PI与放射敏感性密切相关。
