Otoyama K, Katayama I, Nishioka K, Nishiyama S
Nihon Hifuka Gakkai Zasshi. 1989 Apr;99(5):537-41.
We have analyzed the relationship between anti-cardiolipin antibody titer and manifestations in 68 patients with systemic lupus erythematosus (SLE), 25 patients with progressive systemic sclerosis (PSS), 37 patients with Sjögren's syndrome and 16 patients with anaphylactoid purpura. Elevated anti-cardiolipin antibody titer was observed in SLE and Sjögren's syndrome. Clinical manifestations correlated with elevated anti-cardiolipin antibody titer included discoid lesion, thrombotic lesion, thrombocytopenia, elevated titer of ds-DNA antibodies, lower serum CPK level, and liver dysfunctions. Anti-cardiolipin antibody titer also correlated with the score of diagnostic criteria for SLE and the history of corticosteroid therapy. These results suggested that anti-cardiolipin antibody positive SLE patients are much more prone to develop thrombotic lesions and that cell bound antibody might play some role for the induction of vascular injury and thrombocytopenia in SLE.
我们分析了68例系统性红斑狼疮（SLE）患者、25例进行性系统性硬化症（PSS）患者、37例干燥综合征患者和16例过敏性紫癜患者的抗心磷脂抗体滴度与临床表现之间的关系。在SLE和干燥综合征患者中观察到抗心磷脂抗体滴度升高。与抗心磷脂抗体滴度升高相关的临床表现包括盘状皮损、血栓形成性病变、血小板减少、双链DNA抗体滴度升高、血清肌酸磷酸激酶水平降低以及肝功能障碍。抗心磷脂抗体滴度还与SLE诊断标准评分及皮质类固醇治疗史相关。这些结果提示，抗心磷脂抗体阳性的SLE患者更容易发生血栓形成性病变，且细胞结合抗体可能在SLE的血管损伤和血小板减少的诱导中起一定作用。
