轻度冷暴露期间非寒战产热（NST）的季节性变化。
Seasonal variation of non-shivering thermogenesis (NST) during mild cold exposure.
作者信息
Nishimura Takayuki, Motoi Midori, Egashira Yuka, Choi Damee, Aoyagi Kiyoshi, Watanuki Shigeki
出版信息
J Physiol Anthropol. 2015 Mar 13;34(1):11. doi: 10.1186/s40101-015-0051-9.
BACKGROUND
The physiological function of non-shivering thermogenesis (NST) has been investigated in recent years, and some studies have discussed the importance of NST with respect to human cold adaptation. The present study aimed to clarify individual and seasonal variations in NST that occurred as a result of mild cold exposure.
METHODS
Seventeen male university students participated in the present study during summer and winter. The climate chamber used was programmed so that ambient temperature dropped from 28°C to 16°C over an 80-min period. Physiological parameters of test subjects were recorded during the experiments.
RESULTS
Increases in oxygen intake (VO2) during cold exposure were significantly greater without shivering in winter than they were in summer. Respiratory exchange ratio (RER) was significantly lower during thermoneutral baseline and cold exposure in winter than it was during the same periods in summer. In addition, there was a significant negative correlation between ΔVO2 and ΔRER.
CONCLUSIONS
Increase of VO2 without shivering indicated increase of NST, and decrease of RER depends on the metabolization of fat in winter. These results suggested that NST activity was activated by seasonal acclimatization, and individual variation of NST depends on individual variation of fat metabolism.
背景
近年来，人们对非颤抖性产热（NST）的生理功能进行了研究，一些研究探讨了NST在人类冷适应方面的重要性。本研究旨在阐明轻度冷暴露导致的NST个体差异和季节性变化。
方法
17名男性大学生在夏季和冬季参与了本研究。所使用的气候舱经过编程，使环境温度在80分钟内从28°C降至16°C。在实验过程中记录受试对象的生理参数。
结果
冷暴露期间，冬季不颤抖时的摄氧量（VO2）增加显著大于夏季。冬季热中性基线和冷暴露期间的呼吸交换率（RER）显著低于夏季同期。此外，ΔVO2与ΔRER之间存在显著负相关。
结论
不颤抖时VO2增加表明NST增加，冬季RER降低取决于脂肪代谢。这些结果表明，NST活性通过季节性适应而被激活，NST的个体差异取决于脂肪代谢的个体差异。
Zotero 插件