Ahern Jennifer, Balzer Laura, Galea Sandro
Division of Epidemiology, School of Public Health, University of California, Berkeley, 101 Haviland Hall, Berkeley, CA 94720-7358, USA.
Division of Biostatistics, School of Public Health, University of California, Berkeley, 101 Haviland Hall, Berkeley, CA 94720-7358, USA.
Drug Alcohol Depend. 2015 Jun 1;151:144-50. doi: 10.1016/j.drugalcdep.2015.03.014. Epub 2015 Mar 24.
Alcohol outlet density and norms shape alcohol consumption. However, due to analytic challenges we do not know: (a) if alcohol outlet density and norms also shape alcohol use disorder, and (b) whether they act in combination to shape disorder.
We applied a new targeted minimum loss-based estimator for rare outcomes (rTMLE) to a general population sample from New York City (N = 4000) to examine the separate and combined relations of neighborhood alcohol outlet density and norms around drunkenness with alcohol use disorder. Alcohol use disorder was assessed using the World Mental Health Comprehensive International Diagnostic Interview (WMH-CIDI) alcohol module. Confounders included demographic and socioeconomic characteristics, as well as history of drinking prior to residence in the current neighborhood.
Alcohol use disorder prevalence was 1.78%. We found a marginal risk difference for alcohol outlet density of 0.88% (95% CI 0.00-1.77%), and for norms of 2.05% (95% CI 0.89-3.21%), adjusted for confounders. While each exposure had a substantial relation with alcohol use disorder, there was no evidence of additive interaction between the exposures.
Results indicate that the neighborhood environment shapes alcohol use disorder. Despite the lack of additive interaction, each exposure had a substantial relation with alcohol use disorder and our findings suggest that alteration of outlet density and norms together would likely be more effective than either one alone. Important next steps include development and testing of multi-component intervention approaches aiming to modify alcohol outlet density and norms toward reducing alcohol use disorder.
酒精销售点密度和规范影响酒精消费。然而,由于分析上的挑战,我们并不清楚:(a)酒精销售点密度和规范是否也会影响酒精使用障碍;(b)它们是否共同作用影响该障碍。
我们将一种针对罕见结局的基于最小损失的新靶向估计器(rTMLE)应用于纽约市的一个普通人群样本(N = 4000),以研究邻里酒精销售点密度和醉酒规范与酒精使用障碍之间的单独及联合关系。使用世界心理健康综合国际诊断访谈(WMH - CIDI)酒精模块评估酒精使用障碍。混杂因素包括人口统计学和社会经济特征,以及在当前邻里居住之前的饮酒史。
酒精使用障碍患病率为1.78%。在对混杂因素进行调整后,我们发现酒精销售点密度的边际风险差异为0.88%(95%置信区间0.00 - 1.77%),规范的边际风险差异为2.05%(95%置信区间0.89 - 3.21%)。虽然每种暴露因素都与酒精使用障碍有显著关系,但没有证据表明这些暴露因素之间存在相加交互作用。
结果表明邻里环境会影响酒精使用障碍。尽管缺乏相加交互作用,但每种暴露因素都与酒精使用障碍有显著关系,我们的研究结果表明,同时改变销售点密度和规范可能比单独改变其中任何一个更有效。接下来重要的步骤包括开发和测试旨在改变酒精销售点密度和规范以减少酒精使用障碍的多成分干预方法。