Leiden University, Institute for Psychological Research, Cognitive Psychology, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands; Leiden Institute for Brain and Cognition, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Winclove Probiotics, Hulstweg 11, 1032 LB Amsterdam, The Netherlands.
Brain Behav Immun. 2015 Aug;48:258-64. doi: 10.1016/j.bbi.2015.04.003. Epub 2015 Apr 7.
Recent insights into the role of the human microbiota in cognitive and affective functioning have led to the hypothesis that probiotic supplementation may act as an adjuvant strategy to ameliorate or prevent depression.
Heightened cognitive reactivity to normal, transient changes in sad mood is an established marker of vulnerability to depression and is considered an important target for interventions. The present study aimed to test if a multispecies probiotic containing Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, and Lactococcus lactis (W19 and W58) may reduce cognitive reactivity in non-depressed individuals.
In a triple-blind, placebo-controlled, randomized, pre- and post-intervention assessment design, 20 healthy participants without current mood disorder received a 4-week probiotic food-supplement intervention with the multispecies probiotics, while 20 control participants received an inert placebo for the same period. In the pre- and post-intervention assessment, cognitive reactivity to sad mood was assessed using the revised Leiden index of depression sensitivity scale.
Compared to participants who received the placebo intervention, participants who received the 4-week multispecies probiotics intervention showed a significantly reduced overall cognitive reactivity to sad mood, which was largely accounted for by reduced rumination and aggressive thoughts.
These results provide the first evidence that the intake of probiotics may help reduce negative thoughts associated with sad mood. Probiotics supplementation warrants further research as a potential preventive strategy for depression.
最近人们对人类微生物群在认知和情感功能中的作用有了新的认识，这使得人们假设益生菌补充剂可能作为一种辅助策略来改善或预防抑郁症。
对悲伤情绪正常、短暂变化的认知反应增强是易患抑郁症的一个既定标志，被认为是干预的一个重要目标。本研究旨在测试含有双歧杆菌 Bifidobacterium bifidum W23、乳双歧杆菌 Bifidobacterium lactis W52、嗜酸乳杆菌 Lactobacillus acidophilus W37、短乳杆菌 Lactobacillus brevis W63、干酪乳杆菌 Lactobacillus casei W56、唾液乳杆菌 Lactobacillus salivarius W24 和嗜热链球菌 Lactococcus lactis（W19 和 W58）的多菌种益生菌是否可以减少非抑郁个体的认知反应。
在一项三盲、安慰剂对照、随机、干预前后评估设计中，20 名没有当前情绪障碍的健康参与者接受了为期 4 周的多菌种益生菌食品补充剂干预，而 20 名对照参与者在同一时期接受了惰性安慰剂。在干预前后的评估中，使用修订后的莱顿抑郁敏感量表评估了悲伤情绪的认知反应。
与接受安慰剂干预的参与者相比，接受为期 4 周的多菌种益生菌干预的参与者对悲伤情绪的整体认知反应显著降低，这主要归因于沉思和攻击想法的减少。
这些结果首次提供了证据表明，摄入益生菌可能有助于减少与悲伤情绪相关的消极想法。益生菌补充剂值得进一步研究，作为预防抑郁症的潜在策略。
