Scaramucci Taís, Borges Alessandra B, Lippert Frank, Zero Domenick T, Hara Anderson T
Am J Dent. 2015 Feb;28(1):18-22.
To evaluate the ability of calcium-containing prescription-strength fluoride (F) toothpastes in preventing enamel erosion under low salivary flow simulating conditions.
Enamel and dentin bovine specimens were assigned to the following groups: A - placebo; B - 1,100 ppm F/NaF (Aquafresh Advanced); C - 5,000 ppm F/NaF (Prevident 5000 Booster); D - 5000 ppm F/NaF+calcium sodium phosphosilicate (Topex Renew); and E - 5,000 ppm F/NaF+tri-calcium phosphate (Clinpro 5000). Specimens were positioned in custom-made devices, creating a sealed chamber on the surface, connected to peristaltic pumps. Citric acid was injected into the chamber for 2 minutes, followed by artificial saliva (0.05 ml/minute), for 60 minutes, 4x/day, for 3 days. Aquafresh was also tested under normal salivary flow (0.5 ml/minute), as reference (Group F). Specimens were exposed to the toothpastes for 2 minutes, 2x/day. After cycling, surface loss (SL) and concentration of loosely- and firmly-bound F were determined. Data were analyzed by ANOVA. Results: Group A (placebo) presented highest surface loss (SL), while Group F had the lowest, for both substrates. For enamel, none of the dentifrices differed from Group B or among each other. For dentin, none of the dentifrices differed from Group B, but Group E showed greater protection than Group C. Group E presented the highest F concentrations for both substrates, only matched by Group D for firmly-bound fluoride on enamel. All fluoridated dentifrices tested reduced SL, with no additional benefit from higher F concentrations. Some formulations, especially Clinpro 5000, increased F availability on the dental substrates, but no further erosion protection was observed.
评估含处方强度氟（F）的含钙牙膏在模拟低唾液流量条件下预防牙釉质侵蚀的能力。
将牙釉质和牙本质牛标本分为以下几组：A组 - 安慰剂组；B组 - 1100 ppm F/氟化钠（佳洁士全优护理牙膏）；C组 - 5000 ppm F/氟化钠（高露洁防敏牙膏加强型）；D组 - 5000 ppm F/氟化钠 + 磷酸硅钙钠（舒适达修复牙膏）；E组 - 5000 ppm F/氟化钠 + 磷酸三钙（高露洁全效抗敏牙膏）。将标本放置在定制装置中，在表面形成一个密封腔室，连接到蠕动泵。向腔室中注入柠檬酸2分钟，然后注入人工唾液（0.05毫升/分钟），持续60分钟，每天4次，共3天。佳洁士牙膏也在正常唾液流量（0.5毫升/分钟）下进行测试，作为对照（F组）。标本每天2次接触牙膏2分钟。循环处理后，测定表面损失（SL）以及松散结合和牢固结合的氟浓度。数据采用方差分析进行分析。结果：对于两种基质，A组（安慰剂组）表面损失最高，而F组最低。对于牙釉质，所有牙膏组与B组之间以及各牙膏组之间均无差异。对于牙本质，所有牙膏组与B组之间无差异，但E组比C组显示出更好的保护作用。E组在两种基质上的氟浓度最高，在牙釉质上牢固结合的氟方面仅与D组相当。所有测试的含氟牙膏均降低了表面损失，较高的氟浓度并无额外益处。一些配方，尤其是高露洁全效抗敏牙膏，增加了牙面基质上氟的可用性，但未观察到进一步减少侵蚀的保护作用。
