Black Jessica J, Clark Duncan B, Martin Christopher S, Kim Kevin H, Blaze Thomas J, Creswell Kasey G, Chung Tammy
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania.
Department of Education, University of Pittsburgh, Pittsburgh, Pennsylvania.
Alcohol Clin Exp Res. 2015 Jun;39(6):1008-15. doi: 10.1111/acer.12711. Epub 2015 Apr 10.
There is limited knowledge of the course of social anxiety disorder (SAD) from adolescence into adulthood, and how SAD and alcohol use disorder (AUD) symptoms change together over time. The current study examined how persistent and adolescent-limited SAD relate to alcohol symptom trajectories across adolescence and into adulthood, as well as gender differences in the course of SAD and AUD symptoms.
Participants were 788 youth (ages 12 to 18 at the baseline assessment; 46.2% female; 80.5% White) recruited from the community (n = 220) and from clinical programs (n = 568). Youth completed clinical interviews on their lifetime history of AUD symptoms and SAD at baseline and were followed through age 25. Multivariate polynomial growth mixture modeling was used to estimate developmental trajectories for SAD and AUD symptoms separately, then together in a dual trajectory model. Gender differences were examined using a classify-analyze approach.
Three SAD trajectory classes were identified: adolescent-limited (15%), persistent (6%), and no SAD (79%). For AUD symptoms, 5 trajectories were identified: severe (10%), moderate (22%), remitting (18%), young adult onset (22%), and stable low (28%). Those with a history of SAD were about twice as likely to be in the severe AUD symptom class compared to those without a history of SAD. Compared to those with persisting SAD, those in the adolescent-limited SAD class were more likely to belong to the stable low AUD trajectory. Compared to males with SAD, females with SAD were less likely to be in the moderate AUD symptom class and were more likely to be in stable low and young adult onset AUD symptom classes.
A history of SAD was associated with membership in the severe AUD trajectory group. The association of gender with SAD and AUD differed depending on developmental period. Future research should examine whether treating SAD in early adolescence may prevent subsequent AUD symptoms.
从青春期到成年期,人们对社交焦虑障碍(SAD)的病程以及SAD和酒精使用障碍(AUD)症状如何随时间共同变化的了解有限。当前研究考察了持续性SAD和青少年局限性SAD与整个青春期及成年期酒精症状轨迹的关系,以及SAD和AUD症状病程中的性别差异。
参与者为788名青少年(基线评估时年龄在12至18岁;46.2%为女性;80.5%为白人),从社区(n = 220)和临床项目(n = 568)招募而来。青少年在基线时完成了关于其终生AUD症状和SAD病史的临床访谈,并随访至25岁。使用多变量多项式增长混合模型分别估计SAD和AUD症状的发展轨迹,然后在双轨迹模型中共同估计。使用分类分析方法检验性别差异。
确定了三个SAD轨迹类别:青少年局限性(15%)、持续性(6%)和无SAD(79%)。对于AUD症状,确定了5个轨迹:重度(10%)、中度(22%)、缓解性(18%)、青年成人期起病(22%)和稳定低水平(28%)。有SAD病史的人处于重度AUD症状类别的可能性是没有SAD病史者的两倍左右。与持续性SAD者相比,青少年局限性SAD类别者更有可能属于稳定低水平AUD轨迹。与患有SAD的男性相比,患有SAD的女性处于中度AUD症状类别的可能性较小,而处于稳定低水平和青年成人期起病AUD症状类别的可能性较大。
SAD病史与重度AUD轨迹组的成员身份相关。性别与SAD和AUD的关联因发育时期而异。未来研究应考察在青春期早期治疗SAD是否可预防随后的AUD症状。