Peng Bo, Meyerhoff Mark E
Department of Chemistry, The University of Michigan, 930 North University Ave., Ann Arbor, MI 48109, USA.
Electroanalysis. 2013 Apr;25(4):914-921. doi: 10.1002/elan.201200445.
We report here on the electrochemical reduction of -nitrosothiol species (RSNO). Nitric oxide (NO) is the reported common product from electrochemically reduced RSNOs at physiological pH. However, studies here at pH 7.4 show that during the reduction of RSNOs (-0.6 V to -0.9 V, vs. Ag/AgCl), no significant amount of NO is detected. Gas analysis suggests RSNO are reduced to nitrous oxide (NO) at pH 7.4 and can only be converted back to NO at more oxidizing voltages. Interestingly, at pH 4.0, a direct one-electron reduction of RSNOs appears to occur and generates significant amounts of NO from RSNO species.
我们在此报告亚硝基硫醇类物质（RSNO）的电化学还原情况。一氧化氮（NO）是在生理pH值下电化学还原RSNOs时报道的常见产物。然而，在pH 7.4条件下的研究表明，在RSNOs还原过程中（相对于Ag/AgCl为-0.6 V至-0.9 V），未检测到大量的NO。气体分析表明，RSNO在pH 7.4时被还原为一氧化二氮（N₂O），并且只有在更具氧化性的电压下才能转化回NO。有趣的是，在pH 4.0时，RSNOs似乎会发生直接的单电子还原，并从RSNO物种中产生大量的NO。
