Division of Hematology, Oncology, and Transplantation, University of Minnesota, 420 Delaware Street, MMC 480, Minneapolis, MN 55455, USA.
Department of Public Health and Preventive Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
J Immunol Res. 2015;2015:952571. doi: 10.1155/2015/952571. Epub 2015 Mar 17.
Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of pregnant women (N = 16) at median of 18 time points tested, from the first trimester through to parturition, per woman. Unconditional growth modeling was then used to determine time-dependent changes in levels of these cytokines. Macrophage-derived chemokine (MDC, aka CCL22) decreases as pregnancy progresses. IL-1β, IL-6, IL-8, IL-12p70, IL-13, IL-15, IP-10, and FLT3-ligand increase as a function of gestational weeks, and IFNα2, IL-1ra, IL-3, IL-9, IL-12p40, and soluble CD40 ligand increase as a function of trimester. As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed.
几项最近的研究表明，妊娠不同阶段母体免疫环境存在差异，但大多数研究都是横断面研究或时间点相对较少。使用基于多重微珠的检测方法，对 16 名孕妇队列的存档血清进行了 42 种细胞因子的检测，中位数为 18 个检测时间点，每个时间点代表一名孕妇从孕早期到分娩的情况。然后使用无条件生长模型来确定这些细胞因子水平随时间的变化。随着妊娠的进展，巨噬细胞来源的趋化因子（MDC，也称为 CCL22）减少。IL-1β、IL-6、IL-8、IL-12p70、IL-13、IL-15、IP-10 和 FLT3 配体随着妊娠周数的增加而增加，IFNα2、IL-1ra、IL-3、IL-9、IL-12p40 和可溶性 CD40 配体随着妊娠月份的增加而增加。随着妊娠的正常进展，母体从 2 型免疫反应偏向转变为炎症/拮抗反应。
