Pierson Elizabeth E, Contino Nathan C, Keifer David Z, Jarrold Martin F
Chemistry Department, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN, 47405, USA.
J Am Soc Mass Spectrom. 2015 Jul;26(7):1213-20. doi: 10.1007/s13361-015-1126-x. Epub 2015 Apr 14.
Charge detection mass spectrometry (CDMS) provides a direct measure of the mass of individual ions through nondestructive, simultaneous measurements of the mass to charge ratio and the charge. To improve the accuracy of the charge measurement, ions are trapped and recirculated through the charge detector. By substantially extending the trapping time, the uncertainty in the charge determination has been reduced by a factor of two, from 1.3 elementary charges (e) to 0.65 e. The limit of detection (the smallest charge that can be reliably measured) has been reduced by about the same proportion, from 13 to 7 e. The more precise charge measurements enable a substantial improvement in the mass resolution, which is critical for applications of CDMS to mixtures of high mass ions.
电荷检测质谱法（CDMS）通过对质荷比和电荷进行非破坏性的同步测量，直接测定单个离子的质量。为提高电荷测量的准确性，离子被捕获并通过电荷检测器进行循环。通过大幅延长捕获时间，电荷测定的不确定性降低了一半，从1.3个基本电荷（e）降至0.65 e。检测限（能够可靠测量的最小电荷量）也降低了大约相同的比例，从13 e降至7 e。更精确的电荷测量使得质量分辨率得到显著提高，这对于CDMS应用于高质量离子混合物至关重要。
