Calabrese Edward J
Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Homeopathy. 2015 Apr;104(2):83-9. doi: 10.1016/j.homp.2015.01.001. Epub 2015 Feb 25.
The present paper provides an historical assessment of the concept of hormesis and its relationship to homeopathy and modern medicine. It is argued that the dose-response concept was profoundly influenced by the conflict between homeopathy and traditional medicine and that decisions on which dose-response model to adopt were not based on "science" but rater on historical antipathies. While the historical dispute between homeopathy and traditional medicine has long since subsided, their impact upon the field has been enduring and generally unappreciated, profoundly adversely affecting current drug development, therapeutic strategies and environmental risk assessment strategies and policies.
本文对兴奋效应的概念及其与顺势疗法和现代医学的关系进行了历史评估。有人认为，剂量反应概念深受顺势疗法与传统医学之间冲突的影响，而且关于采用何种剂量反应模型的决策并非基于“科学”，而是基于历史上的反感。虽然顺势疗法与传统医学之间的历史争议早已平息，但其对该领域的影响却持久且普遍未得到重视，对当前药物研发、治疗策略以及环境风险评估策略和政策产生了深远的不利影响。
