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[二甲双胍诱发的乳酸性酸中毒:症状严重且诊断困难]

[Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics].

作者信息

Decker S O, Wortmann M, Siegler B H, Ulrich A, Hofer S, Brenner T

机构信息

Klinik für Anästhesiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland,

出版信息

Anaesthesist. 2015 Apr;64(4):292-7. doi: 10.1007/s00101-015-0017-7. Epub 2015 Apr 14.

Abstract

Metformin-induced lactic acidosis is a rare but severe disease for the individual patients. A case of a 64-year-old patient with diabetes mellitus type 2 suffering from this disease is presented where metformin accumulation was caused by prerenal acute kidney failure. The clinical evaluation up to the final diagnosis, the pathophysiology and the appropriate therapy are presented in detail. Additionally, the current guidelines regarding the perioperative management of metformin administration are summarized. The case described aims to direct attention to the rare but, nevertheless, severe symptoms of metformin-induced lactic acidosis.

摘要

二甲双胍诱发的乳酸性酸中毒对个体患者而言是一种罕见但严重的疾病。本文介绍了一例64岁2型糖尿病患者罹患此病的病例,其二甲双胍蓄积是由肾前性急性肾衰竭所致。详细阐述了直至最终诊断的临床评估、病理生理学及恰当治疗。此外,还总结了当前关于二甲双胍围手术期管理的指南。所描述的病例旨在引起人们对二甲双胍诱发乳酸性酸中毒这种罕见但严重症状的关注。

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