Jabs D A, Fine S L, Hochberg M C, Newman S A, Heiner G G, Stevens M B
Arch Ophthalmol. 1986 Apr;104(4):558-63. doi: 10.1001/archopht.1986.01050160114025.
Retinopathy in systemic lupus erythematosus generally consists of cotton-wool spots with or without intraretinal hemorrhages. Although rare, a more severe retinal vaso-occlusive disease, termed retinal vasculitis, has been described. We report data from 11 patients with SLE and severe retinal vaso-occlusive disease. Visual outcome was often poor, with 55% of the involved eyes suffering visual loss, frequently to an acuity of worse than 20/200. The systemic feature significantly associated with severe retinal vascular disease was central nervous system involvement (CNS lupus), present in eight (73%) of the 11 patients vs an overall prevalence of 37%. The association of CNS lupus with severe retinal vaso-occlusive disease probably reflects a similar pathogenetic mechanism and microangiopathy.
系统性红斑狼疮视网膜病变通常由棉絮斑组成，可伴有或不伴有视网膜内出血。虽然罕见，但有一种更严重的视网膜血管闭塞性疾病，称为视网膜血管炎，已有相关描述。我们报告了11例患有系统性红斑狼疮和严重视网膜血管闭塞性疾病患者的数据。视力预后通常较差，55%的受累眼睛出现视力丧失，视力经常低于20/200。与严重视网膜血管疾病显著相关的全身特征是中枢神经系统受累（中枢神经系统狼疮），11例患者中有8例（73%）出现，而总体患病率为37%。中枢神经系统狼疮与严重视网膜血管闭塞性疾病的关联可能反映了相似的发病机制和微血管病变。
