人乳头瘤病毒DNA检测对子宫颈癌前病变的临床意义。
Clinical significance of HPV-DNA testing for precancerous cervical lesions.
作者信息
Moarcăs M, Georgescu I C, Brătilă E, Badea M, Cîrstoiu M
机构信息
Obstetrics and Gynaecology Department, University Emergency Hospital, Bucharest.
Obstetrics and Gynaecology Department, "Sf. Pantelimon" Emergency Hospital.
出版信息
J Med Life. 2014;7 Spec No. 3(Spec Iss 3):37-9.
Abstract
Cervical screening by using cytology was proven efficient in reducing the mortality secondary to cervical cancer, but this method has limitations. High risk HPV infection is essential for cervical cancer development so HPV testing is a new tool used for screening patients for cervical neoplasia. HPV testing was proven most useful for women over 30 years old, in cases in which cytology identified ASC-US and after treatment for CIN. This article outlines the clinical significance of HPV-DNA testing for precancerous cervical lesions and the evidence that stands behind these recommendations.
摘要
通过细胞学进行宫颈筛查已被证明在降低宫颈癌继发死亡率方面是有效的，但这种方法存在局限性。高危型人乳头瘤病毒（HPV）感染是宫颈癌发生的必要条件，因此HPV检测是用于筛查宫颈肿瘤患者的一种新工具。HPV检测已被证明对30岁以上女性最为有用，适用于细胞学检查发现非典型鳞状细胞不能明确意义（ASC-US）的情况以及宫颈上皮内瘤变（CIN）治疗后。本文概述了HPV-DNA检测对宫颈癌前病变的临床意义以及这些建议背后的证据。
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本文引用的文献
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American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.美国癌症协会、美国阴道镜和宫颈病理学会以及美国临床病理学会宫颈癌预防和早期检测筛查指南。
J Low Genit Tract Dis. 2012 Jul;16(3):175-204. doi: 10.1097/LGT.0b013e31824ca9d5.
2
High-risk human papillomavirus testing versus cytology in predicting post-treatment disease in women treated for high-grade cervical disease: a systematic review and meta-analysis.高危型人乳头瘤病毒检测与细胞学检查在预测高级别宫颈疾病治疗后疾病中的作用：系统评价和荟萃分析。
Gynecol Oncol. 2012 May;125(2):500-7. doi: 10.1016/j.ygyno.2012.01.015. Epub 2012 Jan 18.
3
Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice.在常规临床实践中同时进行人乳头瘤病毒和宫颈细胞学检测的女性宫颈癌风险：一项基于人群的研究。
Lancet Oncol. 2011 Jul;12(7):663-72. doi: 10.1016/S1470-2045(11)70145-0. Epub 2011 Jun 16.
4
High-risk human papillomavirus testing in women with ASC-US cytology: results from the ATHENA HPV study.人乳头瘤病毒高危型检测在 ASC-US 细胞学检查中的应用：ATHENA HPV 研究结果。
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5
Type-specific HPV geno-typing improves detection of recurrent high-grade cervical neoplasia after conisation.针对 HPV 型别进行基因分型可提高锥切术后复发高级别宫颈上皮内瘤样病变的检出率。
Int J Cancer. 2011 Aug 15;129(4):903-9. doi: 10.1002/ijc.25745. Epub 2011 Feb 11.
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