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通过磁共振成像测量肝脏铁浓度具有可重复性。

Measurement of liver iron concentration by MRI is reproducible.

作者信息

Alústiza José María, Emparanza José I, Castiella Agustín, Casado Alfonso, Garrido Adolfo, Aldazábal Pablo, San Vicente Manuel, Garcia Nerea, Asensio Ana Belén, Banales Jesús, Salvador Emma, Moyua Aranzazu, Arozena Xabier, Zarco Miguel, Jauregui Lourdes, Vicente Ohiana

机构信息

Osatek, Donostia Universitary Hospital, P. Dr. Beguiristain 109, 20014 Donostia/San Sebastián, Spain.

Clinical Epidemiology, Donostia Universitary Hospital, P. Dr. Beguiristain 117, 20080 Donostia/San Sebastián, Spain.

出版信息

Biomed Res Int. 2015;2015:294024. doi: 10.1155/2015/294024. Epub 2015 Mar 22.

DOI:10.1155/2015/294024
PMID:25874207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4385637/
Abstract

PURPOSE

The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients.

MATERIALS AND METHODS

A phantom reproducing the liver/muscle ratios of two patients with intermediate and high iron overload. Nine patients with different levels of iron overload were studied in 4 multivendor devices and 8 of them were studied twice in the machine where the model was developed. The phantom was analysed in the same equipment and 14 times in the reference machine.

RESULTS

FeCl3 solutions containing 0.3, 0.5, 0.6, and 1.2 mg Fe/mL were chosen to generate the phantom. The average of the intramachine variability for patients was 10% and for the intermachines 8%. For the phantom the intramachine coefficient of variation was always below 0.1 and the average of intermachine variability was 10% for moderate and 5% for high iron overload.

CONCLUSION

The phantom reproduces the behavior of patients with moderate or high iron overload. The proposed method of calculating liver iron concentration is reproducible in several different 1.5 T systems.

摘要

目的

目标是（i）构建一个体模，通过磁共振成像（MRI）再现肝脏中铁过载的情况，以及（ii）使用该体模和患者评估一种先前验证的定量肝脏铁浓度的方法在不同MRI设备之间的变异性。

材料与方法

构建一个体模，再现两名中度和高度铁过载患者的肝脏/肌肉比率。在4台多厂商设备中研究了9名不同铁过载水平的患者，其中8名患者在开发该模型的机器上进行了两次研究。在相同设备中对体模进行分析，并在参考机器中进行了14次分析。

结果

选择含有0.3、0.5、0.6和1.2mg Fe/mL的FeCl3溶液来生成体模。患者的机器内变异性平均值为10%，机器间变异性为8%。对于体模，机器内变异系数始终低于0.1，中度铁过载的机器间变异性平均值为10%，高度铁过载为5%。

结论

该体模再现了中度或高度铁过载患者的情况。所提出的计算肝脏铁浓度的方法在几种不同的1.5T系统中具有可重复性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/e7d3e5ffedc9/BMRI2015-294024.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/33be57dedbd3/BMRI2015-294024.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/c57a33d24b60/BMRI2015-294024.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/e832f984f376/BMRI2015-294024.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/cd42152a66e2/BMRI2015-294024.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/e7d3e5ffedc9/BMRI2015-294024.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/33be57dedbd3/BMRI2015-294024.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/c57a33d24b60/BMRI2015-294024.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/e832f984f376/BMRI2015-294024.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/cd42152a66e2/BMRI2015-294024.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bdc/4385637/e7d3e5ffedc9/BMRI2015-294024.005.jpg

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