Sali Michela, Buttinelli Gabriele, Fazio Cecilia, Vacca Paola, La Sorda Marilena, Carannante Anna, Spanu Teresa, Valentini Piero, Stefanelli Paola
a Institute of Microbiology; Università Cattolica del Sacro Cuore ; Rome , Italy.
Hum Vaccin Immunother. 2015;11(5):1173-4. doi: 10.1080/21645515.2015.1019190.
We report pertussis cases in 4 infants less than 6 months admitted with symptoms compatible with pertussis to the intensive care unit of the Università Cattolica del Sacro Cuore in Rome, April 2014. Realtime PCR confirmed pertussis diagnosis for the 4 infants, 2 of them were cousins, and for the household contacts of 1 of them. Analysis of pertussis toxin, its promoter and pertactin was also performed. First of all, this report emphasizes the need to investigate household contact of infants with pertussis; secondly, to evaluate the selective vaccination of household members of newborns as an effective program to reduce pertussis in infants.
2014年4月，我们报告了罗马圣心天主教大学重症监护病房收治的4名6个月以下出现百日咳相关症状的婴儿的百日咳病例。实时荧光定量聚合酶链反应（Real-time PCR）确诊这4名婴儿患有百日咳，其中2名是表亲，还确诊了其中1名婴儿的家庭接触者患有百日咳。同时还对百日咳毒素、其启动子和丝状血凝素进行了分析。首先，本报告强调有必要对百日咳婴儿的家庭接触者进行调查；其次，评估对新生儿家庭成员进行选择性疫苗接种作为减少婴儿百日咳的有效方案。
