NHC 催化的烯醛和 α-酮酰胺的手性合成功能化琥珀酰亚胺。
NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany).
出版信息
Chemistry. 2015 May 26;21(22):8033-7. doi: 10.1002/chem.201500661. Epub 2015 Apr 15.
Abstract
The efficient asymmetric synthesis of highly substituted succinimides from α,β-unsaturated aldehydes and α-ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides easy access to assemble a wide range of succinimides from simple starting materials.
摘要
通过 NHC 催化的[3+2]环加成反应，从α,β-不饱和醛和α-酮酰胺高效不对称合成了高度取代的琥珀酰亚胺。该新的可扩展方案显著扩展了 NHC 催化在杂环合成中的应用，并为从简单原料组装广泛的琥珀酰亚胺提供了简便方法。
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