Klokker Louise, Osborne Richard, Wæhrens Eva E, Norgaard Ole, Bandak Elisabeth, Bliddal Henning, Henriksen Marius
Department of Rheumatology, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Nordre Fasanvej 57, 2000, Frederiksberg, Copenhagen, Denmark.
Population Health Strategic Research Centre, School of Health and Social Development, Faculty of Health, Deakin University, Burwood, Australia.
Qual Life Res. 2015 Oct;24(10):2423-32. doi: 10.1007/s11136-015-0976-9. Epub 2015 Apr 17.
To comprehensively identify components of the physical limitation concept in knee osteoarthritis (OA) and to rate the clinical importance of these using perspectives of both patients and health professionals.
Concept mapping, a structured group process, was used to identify and organize data in focus groups (patients) and via a global web-based survey (professionals). Ideas were elicited through a nominal group technique and then organized using multidimensional scaling, cluster analysis, participant validation, rating of clinical importance, and thematic analyses to generate a conceptual model of physical limitations in knee OA.
Fifteen Danish patients and 200 international professionals contributed to generating the conceptual model. Five clusters emerged: 'Limitations/physical deficits'; 'Everyday hurdles'; 'You're not the person you used to be'; 'Need to adjust way of living'; and 'External limitations,' each with sub-clusters. Patients generally found their limitations more important than the professionals did.
Patients and professionals agreed largely on the physical limitation concept in knee OA. Some limitations of high importance to patients were lower rated by the professionals, highlighting the importance of including patients when conceptualizing patient outcomes. These data offer new knowledge to guide selection of clinically relevant outcomes and development of outcome measures in knee OA.
全面识别膝关节骨关节炎(OA)身体功能受限概念的组成部分,并从患者和卫生专业人员的角度评估这些组成部分的临床重要性。
采用概念映射法,这是一种结构化的小组流程,通过焦点小组(患者)和基于网络的全球调查(专业人员)来识别和整理数据。通过名义小组技术引出想法,然后使用多维尺度分析、聚类分析、参与者验证、临床重要性评级和主题分析来生成膝关节OA身体功能受限的概念模型。
15名丹麦患者和200名国际专业人员参与生成了概念模型。出现了五个聚类:“功能受限/身体缺陷”;“日常障碍”;“你不再是过去的自己”;“需要调整生活方式”;以及“外部限制”,每个聚类都有子聚类。患者通常认为他们的功能受限比专业人员认为的更重要。
患者和专业人员在很大程度上对膝关节OA的身体功能受限概念达成了一致。一些对患者非常重要的功能受限在专业人员的评级中较低,这突出了在概念化患者结局时纳入患者的重要性。这些数据为指导膝关节OA临床相关结局的选择和结局测量方法的开发提供了新知识。