Stenner Max-Philipp, Dürschmid Stefan, Rutledge Robb B, Zaehle Tino, Schmitt Friedhelm C, Kaufmann Jörn, Voges Jürgen, Heinze Hans-Jochen, Dolan Raymond J, Schoenfeld Mircea Ariel
Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany;
Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
J Neurophysiol. 2016 Oct 1;116(4):1663-1672. doi: 10.1152/jn.00142.2016. Epub 2016 Jul 13.
The human nucleus accumbens is thought to play an important role in guiding future action selection via an evaluation of current action outcomes. Here we provide electrophysiological evidence for a more direct, i.e., online, role during action preparation. We recorded local field potentials from the nucleus accumbens in patients with epilepsy undergoing surgery for deep brain stimulation. We found a consistent decrease in the power of alpha/beta oscillations (10-30 Hz) before and around the time of movements. This perimovement alpha/beta desynchronization was observed in seven of eight patients and was present both before instructed movements in a serial reaction time task as well as before self-paced, deliberate choices in a decision making task. A similar beta decrease over sensorimotor cortex and in the subthalamic nucleus has been directly related to movement preparation and execution. Our results support the idea of a direct role of the human nucleus accumbens in action preparation and execution.
人类伏隔核被认为在通过评估当前行动结果来指导未来行动选择方面发挥重要作用。在此，我们提供了电生理证据，证明其在行动准备过程中发挥了更直接的作用，即在线作用。我们记录了接受深部脑刺激手术的癫痫患者伏隔核的局部场电位。我们发现，在运动之前及运动期间，α/β振荡（10 - 30赫兹）的功率持续下降。在八名患者中的七名身上观察到了这种运动周围α/β去同步化现象，且在序列反应时任务中的指令性运动之前以及决策任务中的自主、审慎选择之前均有出现。感觉运动皮层和丘脑底核中类似的β波下降已被直接关联到运动准备和执行。我们的结果支持了人类伏隔核在行动准备和执行中发挥直接作用这一观点。
