Laskar Sarbani Ghosh, Swain Monali
Department of Radiation Oncology, Head and Neck Oncology Disease Management Group, Tata Memorial Centre, Parel, Mumbai, Maharashtra, India.
J Cancer Res Ther. 2015 Jan-Mar;11(1):6-9. doi: 10.4103/0973-1482.151445.
In recent years there has been change in trends in the incidence of head and neck squamous cell carcinoma (HNSCC) with oropharyngeal carcinoma (OPC) showing an increased incidence, attributable specifically to infection by human papillomavirus (HPV). At the same time there is change in demographic characteristics and prognosis of this subset of HNSCC. Considering the better prognosis, researchers are trying to reduce the acute and long-term toxicities by alteration of various components of treatment protocols. Although treatment deintensification is an option for this group of patients, there is no standard protocol available and should be tried only in the protocol setting.
近年来，头颈部鳞状细胞癌（HNSCC）的发病趋势有所变化，口咽癌（OPC）的发病率上升，这尤其归因于人类乳头瘤病毒（HPV）感染。与此同时，HNSCC这一亚组的人口统计学特征和预后也在发生变化。考虑到预后较好，研究人员正试图通过改变治疗方案的各个组成部分来降低急性和长期毒性。尽管对于这组患者来说，减少治疗强度是一种选择，但目前尚无标准方案，且仅应在方案设定的情况下尝试。
