Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Xiamen Medical College, Xiamen, China.
Xiamen Key Laboratory of Stomotalogical Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College, Xiamen, China.
Cancer Med. 2023 Jul;12(13):14718-14730. doi: 10.1002/cam4.6095. Epub 2023 May 18.
The rising cancer incidence in patients with oral leukoplakia (OL) highlights the importance of identifying potential biomarkers for high-risk individuals and lesions because these biomarkers are useful in developing personalized management strategies for OL patients. This study systematically searched and analyzed the literature on potential saliva and serum biomarkers for OL malignant transformation.
PubMed and Scopus were searched for studies published up to April 2022. The primary outcome of this study was the difference in biomarker concentrations in saliva or serum samples from healthy control (HC), OL and oral cancer (OC) populations. Cohen's d with 95% credible interval was calculated and pooled using the inverse variance heterogeneity method.
A total of seven saliva biomarkers were analyzed in this paper, including interleukin-1alpha, interleukin-6 (IL-6), interleukin-6-8, tumor necrosis factor alpha (TNF-α), copper, zinc, and lactate dehydrogenase. IL-6 and TNF-α exhibited statistically significant deviations in comparisons between HC versus OL and OL versus OC. A total of 13 serum biomarkers were analyzed, including IL-6, TNF-α, C-reactive protein, total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, albumin, protein, β2-microglobulin, fucose, lipid-bound sialic acid (LSA), and total sialic acid (TSA). LSA and TSA exhibited statistically significant deviations in comparisons between HC versus OL and OL versus OC.
IL-6 and TNF-α in saliva have strong predictive values for OL deterioration, and LSA and TSA concentration levels in serum also have the potential to serve as biomarkers for OL deterioration.
口腔白斑（OL）患者的癌症发病率不断上升，这凸显了识别高危人群和病变中潜在生物标志物的重要性，因为这些生物标志物有助于为 OL 患者制定个性化的管理策略。本研究系统地检索和分析了与 OL 恶变相关的潜在唾液和血清生物标志物的文献。
检索了截至 2022 年 4 月发表的 PubMed 和 Scopus 中的研究。本研究的主要结局是健康对照组（HC）、OL 和口腔癌（OC）人群的唾液或血清样本中生物标志物浓度的差异。使用逆方差异质性方法计算并合并了 95%可信区间的 Cohen's d。
本文共分析了 7 种唾液生物标志物，包括白细胞介素-1α、白细胞介素-6（IL-6）、白细胞介素-6-8、肿瘤坏死因子-α（TNF-α）、铜、锌和乳酸脱氢酶。HC 与 OL 以及 OL 与 OC 之间的比较中，IL-6 和 TNF-α 表现出统计学显著差异。共分析了 13 种血清生物标志物，包括 IL-6、TNF-α、C 反应蛋白、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、白蛋白、蛋白质、β2-微球蛋白、岩藻糖、脂质结合唾液酸（LSA）和总唾液酸（TSA）。HC 与 OL 以及 OL 与 OC 之间的比较中，LSA 和 TSA 浓度表现出统计学显著差异。
唾液中的 IL-6 和 TNF-α 对 OL 恶化具有较强的预测价值，血清中的 LSA 和 TSA 浓度也有可能成为 OL 恶化的生物标志物。
