Shetty Shishir Ram, Babu Subhas, Kumari Suchetha, Shetty Pushparaja, Hegde Shruthi, Karikal Arvind
Department of Oral Medicine and Radiology, AB Shetty memorial Institute of Dental Science, Mangalore, Karnataka, India.
J Cancer Res Ther. 2015 Jan-Mar;11(1):146-9. doi: 10.4103/0973-1482.137973.
Several studies in recent years have linked association between micronutrient levels and various forms of cancer. Copper and zinc have been the most researched micronutrients.
The aim of the study was to evaluate the levels of copper, zinc and iron in saliva of patients with oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma.
There was a highly significant increase in the level of salivary copper in oral submucous fibrosis patients when compared to controls (P = 0.001). Salivary copper levels were also elevated in oral leukoplakia and oral cancer patients (P = 0.01). There was a significant decrease in the salivary zinc levels in all three study groups when compared to controls (P = 0.001). A highly significant reduction in salivary iron levels was noticed oral submucous fibrosis group. The copper to zinc ratio significantly increased in all the study groups when compared to controls.
Results suggest that salivary copper zinc and iron could be used as biomarkers for oral precancer and cancer.
近年来的多项研究将微量营养素水平与各种癌症形式联系起来。铜和锌是研究最多的微量营养素。
本研究旨在评估口腔白斑、口腔黏膜下纤维化和口腔鳞状细胞癌患者唾液中铜、锌和铁的水平。
与对照组相比，口腔黏膜下纤维化患者唾液铜水平显著升高（P = 0.001）。口腔白斑和口腔癌患者唾液铜水平也升高（P = 0.01）。与对照组相比，所有三个研究组的唾液锌水平均显著降低（P = 0.001）。口腔黏膜下纤维化组唾液铁水平显著降低。与对照组相比，所有研究组的铜锌比均显著增加。
结果表明，唾液铜、锌和铁可用作口腔癌前病变和癌症的生物标志物。
