Freislederer Philipp, Reiner Michael, Hoischen Winfried, Quanz Anton, Heinz Christian, Walter Franziska, Belka Claus, Soehn Matthias
Department of Radiation Oncology, LMU University Hospital, D-81377, Munich, Germany.
Radiat Oncol. 2015 Mar 19;10:68. doi: 10.1186/s13014-015-0376-x.
Knowing the technical characteristics of gated radiotherapy equipment is crucial for ensuring precise and accurate treatment when using techniques such as Deep-Inspiration Breath-Hold and gating under free breathing. With one of the first installations of the novel surface imaging system Catalyst™ (C-RAD AB, Sweden) in connection with an Elekta Synergy linear accelerator (Elekta AB, Sweden) via the Elekta Response Interface, characteristics like dose delivery accuracy and time delay were investigated prior to clinical implementation of gated treatments in our institution.
In this study a moving phantom was used to simulate respiratory motion which was registered by the Catalyst™ system. The gating level was set manually. Within this gating window a trigger signal is automatically sent to the linac initiating treatment delivery. Dose measurements of gated linac treatment beams with different gating levels were recorded with a static 2D-Diode Array (MapCheck2, Sun Nuclear Co., USA) and compared to ungated reference measurements for different field sizes. In addition, the time delay of gated treatment beams was measured using radiographic film.
The difference in dose delivery between gated and ungated treatment decreases with the size of the chosen gating level. For clinically relevant gating levels of about 30%, the differences in dose delivery accuracy remain below 1%. In comparison with other system configurations in literature, the beam-on time delay shows a large deviation of 851 ms ± 100 ms.
When performing gated treatment, especially for free-breathing gating, factors as time delay and dose delivery have to be evaluated regularly in terms of a quality assurance process. Once these parameters are known they can be accounted and compensated for, e.g. by adjusting the pre-selected gating level or the internal target volume margins and by using prediction algorithms for breathing curves. The usage of prediction algorithms becomes inevitable with the high beam-on time delay which is reported here.
了解门控放射治疗设备的技术特性对于在使用深吸气屏气和自由呼吸下的门控等技术时确保精确准确的治疗至关重要。通过Elekta响应接口将新型表面成像系统Catalyst™(瑞典C-RAD AB公司)首次安装在一台Elekta Synergy直线加速器(瑞典Elekta AB公司)上后,在我们机构进行门控治疗的临床应用之前,对剂量输送准确性和时间延迟等特性进行了研究。
在本研究中,使用移动体模模拟呼吸运动,该运动由Catalyst™系统记录。门控水平手动设置。在该门控窗口内,触发信号会自动发送到直线加速器以启动治疗输送。使用静态二维二极管阵列(美国Sun Nuclear公司的MapCheck2)记录不同门控水平的门控直线加速器治疗束的剂量测量值,并与不同射野大小的非门控参考测量值进行比较。此外,使用射线照相胶片测量门控治疗束的时间延迟。
门控治疗和非门控治疗之间的剂量输送差异随所选门控水平的大小而减小。对于约30%的临床相关门控水平,剂量输送准确性的差异仍低于1%。与文献中的其他系统配置相比,束流开启时间延迟显示出851 ms±100 ms的较大偏差。
在进行门控治疗时,尤其是自由呼吸门控,必须在质量保证过程中定期评估时间延迟和剂量输送等因素。一旦知道这些参数,就可以进行考虑和补偿,例如通过调整预先选择的门控水平或内部靶体积边界,并使用呼吸曲线预测算法。鉴于此处报告的高束流开启时间延迟,预测算法的使用变得不可避免。