Adamo Roberto, Nilo Alberto, Castagner Bastien, Boutureira Omar, Berti Francesco, Bernardes Gonçalo J L
Research Center , Novartis Vaccines and Diagnostics , Via Fiorentina 1 , 53100 Siena , Italy . Email:
Department of Chemistry and Applied Biosciences , ETH Zürich , Wolfgang-Pauli-Str. 10 , 8093 Zürich , Switzerland.
Chem Sci. 2013 Aug 1;4(8):2995-3008. doi: 10.1039/c3sc50862e. Epub 2013 May 16.
Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.
疫苗设计中的主要实例表明,使用与蛋白质载体共价偶联的提取或全合成荚膜多糖聚糖引发免疫反应时,能产生良好水平的碳水化合物特异性抗体。在此,我们涵盖了基于碳水化合物的疫苗的最新临床进展,并描述了用于寡糖全合成以及将碳水化合物精确置于蛋白质内预定位点的新型前沿方法如何可用于进一步提高糖疫苗的安全性和有效性。