Al'khovskiĭ S V, L'vov D K, Shchelkanov M Iu, Deriabin P G, Shchetinin A M, Samokhvalov E I, Aristova V A, Gitel'man A K, Botikov A G
Vopr Virusol. 2014;59(5):23-6.
The complete genome of Uzun-Agach virus (UZAV), isolated from the liver of Myotis blythii oxygnathus (Monticelli, 1885 (Chiroptera; Vespertilionidae)) bats in Alma-Ata district (Kazakhstan) in 1977 have been sequenced. Based on full-length genome comparison it is shown that UZAV is a new member of the Nairovirus genus (family Bunyaviridae). L-segment and M-segments of UZAV have 69,3% and 64,1% identity with Issyk-Kul virus (ISKV) that also was isolated from bats. S-segment of UZAV have 99,6% identity with the same of ISKV. This allow us to claim that UZAV is a reassortant virus that have S-segment derived from ISKV, and L- and M-segments from another virus that is phylogenetically related to ISKV, but divergent from it. The obtained data that the reassortment between ISKV and UZAV exists in nature suggest that they cocirculated in one ecological niche (bats of the Vespertilionidae family) and the areal of UZAV may coincide with the areal of ISKV.
1977年，从哈萨克斯坦阿拉木图地区布莱氏鼠耳蝠（Myotis blythii oxygnathus，蒙蒂切利，1885年（翼手目；蝙蝠科））肝脏中分离出的乌尊-阿加奇病毒（UZAV）的全基因组已被测序。基于全长基因组比较表明，UZAV是内罗毕病毒属（布尼亚病毒科）的一个新成员。UZAV的L片段和M片段与同样从蝙蝠中分离出的伊塞克湖病毒（ISKV）分别具有69.3%和64.1%的同源性。UZAV的S片段与ISKV的S片段具有99.6%的同源性。这使我们可以声称，UZAV是一种重配病毒，其S片段来源于ISKV，而L片段和M片段则来源于另一种与ISKV在系统发育上相关但又与其不同的病毒。自然界中存在ISKV和UZAV之间重配的这一数据表明，它们在一个生态位（蝙蝠科蝙蝠）中共存，并且UZAV的分布区域可能与ISKV的分布区域重合。
