Al'khovskiĭ S V, L'vov D K, Shchelkanov M Iu, Shchetinin A M, Deriabin P G, Samokhvalov E I, Gitel'man A K, Botikov A G
Vopr Virusol. 2013 Sep-Oct;58(5):11-5.
The Issyk-Kul virus (etiological agent of the Issyk-Kul fever) was originally isolated from bats (Nyctalus noctula Schreber, 1774 (Chiroptera: Vespertilionidae)) and their parasites ticks (Argas (Carios) vespertilionis Latreille, 1796 (Parasitiformes: Argasidae)) in Kirghizia. Sporadic cases and epidemics of the Issyk-Kul fever are observed in Central Asia since 1979. The ISKV genome was de novo sequenced using the next-generation sequencing technology. According to the molecular-genetic and phylogenetic analysis, the ISKV is a member of a novel group in the genus Nairovirus (Bunyaviridae). Based on the data obtained, molecular-genetic methods can be used for ISKV detection (PCR) for the Issyk-Kul fever monitoring and diagnosis in the endemic areas.
伊塞克湖病毒(伊塞克湖热的病原体)最初是在吉尔吉斯斯坦从蝙蝠(夜蝠,Nyctalus noctula Schreber,1774年(翼手目:蝙蝠科))及其寄生虫蜱(夜蝠锐缘蜱,Argas (Carios) vespertilionis Latreille,1796年(寄螨目:锐缘蜱科))中分离出来的。自1979年以来,中亚地区观察到伊塞克湖热的散发病例和疫情。使用下一代测序技术对伊塞克湖病毒基因组进行了从头测序。根据分子遗传学和系统发育分析,伊塞克湖病毒是内罗病毒属(布尼亚病毒科)中一个新类群的成员。基于所获得的数据,分子遗传学方法可用于伊塞克湖病毒检测(PCR),以监测和诊断疫区的伊塞克湖热。