生活在菌膜中：霍乱弧菌生物被膜的组装与调控
Living in the matrix: assembly and control of Vibrio cholerae biofilms.
作者信息
Teschler Jennifer K, Zamorano-Sánchez David, Utada Andrew S, Warner Christopher J A, Wong Gerard C L, Linington Roger G, Yildiz Fitnat H
机构信息
Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California 95064, USA.
Bioengineering Department, Chemistry and Biochemistry Department, California NanoSystems Institute, University of California, Los Angeles, California 90095, USA.
出版信息
Nat Rev Microbiol. 2015 May;13(5):255-68. doi: 10.1038/nrmicro3433.
Nearly all bacteria form biofilms as a strategy for survival and persistence. Biofilms are associated with biotic and abiotic surfaces and are composed of aggregates of cells that are encased by a self-produced or acquired extracellular matrix. Vibrio cholerae has been studied as a model organism for understanding biofilm formation in environmental pathogens, as it spends much of its life cycle outside of the human host in the aquatic environment. Given the important role of biofilm formation in the V. cholerae life cycle, the molecular mechanisms underlying this process and the signals that trigger biofilm assembly or dispersal have been areas of intense investigation over the past 20 years. In this Review, we discuss V. cholerae surface attachment, various matrix components and the regulatory networks controlling biofilm formation.
几乎所有细菌都会形成生物膜，以此作为生存和持续存在的策略。生物膜与生物和非生物表面相关联，由被自身产生或获取的细胞外基质包裹的细胞聚集体组成。霍乱弧菌作为理解环境病原体中生物膜形成的模式生物而受到研究，因为它在水生环境中的人类宿主之外度过其大部分生命周期。鉴于生物膜形成在霍乱弧菌生命周期中的重要作用，在过去20年中，这一过程的分子机制以及触发生物膜组装或分散的信号一直是深入研究的领域。在本综述中，我们讨论了霍乱弧菌的表面附着、各种基质成分以及控制生物膜形成的调控网络。
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