He Jianglong, Li Xiaoquan, Tang Jialin, Jin Tinli, Liao Qinghua, Hu Guoliang
Department of Infectious Disease, the First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Department of Pediatrics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
Onco Targets Ther. 2015 Apr 7;8:727-34. doi: 10.2147/OTT.S78581. eCollection 2015.
The association between chemotactic chemokine ligand 5 (CCL5) -403G/A gene polymorphism and human immunodeficiency virus-1 (HIV-1) infection has been illustrated among several case-control studies, but the conclusions are still inconsistent. Here we performed a meta-analysis to estimate the association.
The published studies based upon the association between CCL5 -403G/A polymorphism and HIV-1 infection were retrieved from PubMed, Embase, and China National Knowledge Infrastructure database. Quantitative synthesis, including pooled odds ratios (ORs) and 95% confidence intervals (CIs), was performed for all genetic models.
A total of ten studies consisting of 5,127 subjects were included for this meta-analysis. There was no association found between -403G/A polymorphism and HIV-1 infection in the overall analysis under any genetic models. Further stratified by ethnicity, our analysis showed that -403A/A polymorphism significantly decreased the susceptibility to HIV-1 infection in three models: the dominant model (AA+AG vs GG: OR =0.44, 95% CI =0.21-0.94) among Africans, the homozygous model (AA vs GG: OR =0.62, 95% CI =0.242-0.90), and the recessive model (AA vs GG+AG: OR =0.62, 95% CI =0.45-0.93) among Asians.
We found that only Asians and Africans with CCL5 -403A/A polymorphism could be resistant to HIV-1 infection. However, further studies should be performed to evaluate this association on ethnic basis against control groups consisting of individuals who have once been exposed to HIV-1 but are seronegative.
在多项病例对照研究中已阐明趋化因子趋化因子配体5（CCL5）-403G/A基因多态性与人类免疫缺陷病毒1型（HIV-1）感染之间的关联，但结论仍不一致。在此，我们进行了一项荟萃分析以评估这种关联。
从PubMed、Embase和中国知网数据库中检索已发表的基于CCL5 -403G/A多态性与HIV-1感染之间关联的研究。对所有遗传模型进行定量综合分析，包括合并比值比（OR）和95%置信区间（CI）。
本荟萃分析共纳入10项研究，涉及5127名受试者。在任何遗传模型下的总体分析中，未发现-403G/A多态性与HIV-1感染之间存在关联。按种族进一步分层后，我们的分析表明，在三种模型中，-403A/A多态性显著降低了对HIV-1感染的易感性：在非洲人中的显性模型（AA + AG vs GG：OR = 0.44，95% CI = 0.21 - 0.94）、纯合子模型（AA vs GG：OR = 0.62，95% CI = 0.242 - 0.90）以及在亚洲人中的隐性模型（AA vs GG + AG：OR = 0.62，95% CI = 0.45 - 0.93）。
我们发现只有具有CCL5 -403A/A多态性的亚洲人和非洲人可能对HIV-1感染具有抗性。然而，应进一步开展研究，以在种族基础上针对由曾接触过HIV-1但血清学阴性的个体组成的对照组评估这种关联。
