Li Wei, Luo Tian, Yang Yanjuan, Tan Xiuniang, Liu Lifei
Department of Chemistry, Capital Normal University, Beijing 100048, China.
Langmuir. 2015 May 12;31(18):5141-6. doi: 10.1021/la504796v. Epub 2015 Apr 29.
Novel multifunctional poly(ethylene oxide) (PEO) nanofibrous membrane, which contains vesicles constructed by mixed surfactant cetyltrimethylammonium bromide (CTAB)/sodium dodecylbenzenesulfonate (SDBS), has been designed as dual drug-delivery system and fabricated via the electrospinning process. 5-FU and paeonolum, which are hydrophilic and hydrophobic anticancer model drugs, can be dissolved in vesicle solution's bond water and lipid bilayer membranes, respectively. The physicochemical properties of the electrospun nanofibrous membrane were systematically studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), and X-ray diffraction (XRD). Drug release behaviors of the electrospun nanofibrous membrane fabricated with different molar ratio of CTAB/SDBS vesicle solution were investigated. The result showed that the releasing amount of hydrophilic drug presented an ascending release manner, while the hydrophobic one showed a descending release behavior with increasing of the molar ratio of CTAB/SDBS. Moreover, the release amount of drugs from drug delivery system can be controlled by the molar ratio of CTAB/SDBS in the vesicle solution easily and conveniently. The distinct properties can be utilized to encapsulate environmental demanding and quantificational materials.
新型多功能聚环氧乙烷（PEO）纳米纤维膜含有由混合表面活性剂十六烷基三甲基溴化铵（CTAB）/十二烷基苯磺酸钠（SDBS）构建的囊泡，已被设计成双药物递送系统，并通过静电纺丝工艺制备。5-氟尿嘧啶和丹皮酚分别为亲水性和疏水性抗癌模型药物，可分别溶解于囊泡溶液的结合水和脂质双分子层膜中。利用扫描电子显微镜（SEM）、透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）和X射线衍射（XRD）对静电纺纳米纤维膜的物理化学性质进行了系统研究。研究了用不同摩尔比的CTAB/SDBS囊泡溶液制备的静电纺纳米纤维膜的药物释放行为。结果表明，随着CTAB/SDBS摩尔比的增加，亲水性药物的释放量呈上升趋势，而疏水性药物的释放量呈下降趋势。此外，通过囊泡溶液中CTAB/SDBS的摩尔比可以轻松方便地控制药物递送系统中药物的释放量。这些独特的性质可用于包封对环境有要求的定量材料。
