头孢唑林与克林霉素治疗兔实验性金黄色葡萄球菌骨髓炎的比较评价
Comparative evaluation of cefazolin and clindamycin in the treatment of experimental Staphylococcus aureus osteomyelitis in rabbits.
作者信息
Mader J T, Adams K, Morrison L
机构信息
Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77550-2772.
出版信息
Antimicrob Agents Chemother. 1989 Oct;33(10):1760-4. doi: 10.1128/AAC.33.10.1760.
Abstract
A rabbit model for Staphylococcus aureus osteomyelitis was used to compare treatment with clindamycin and cefazolin. Cefazolin (5 mg/kg), cefazolin (15 mg/kg), and clindamycin (70 mg/kg) were injected subcutaneously every 6 h for 28 days. After treatment, S. aureus was found in bone cultures from 22 of 23 control rabbits, 12 of 22 rabbits treated with cefazolin (5 mg/kg), 12 of 23 rabbits treated with cefazolin (15 mg/kg), and 2 of 20 rabbits treated with clindamycin. Drug concentrations in serum, uninfected bone, and infected bone were measured 30 min after cefazolin or clindamycin was injected into a group of rabbits which had been infected for 3 to 4 weeks. Clindamycin gave the highest concentration in infected and uninfected bone. The results of the study showed that clindamycin was superior to cefazolin in the eradication of S. aureus from infected bone in an experimental model.
摘要
采用金黄色葡萄球菌骨髓炎兔模型比较克林霉素和头孢唑林的治疗效果。头孢唑林（5 mg/kg）、头孢唑林（15 mg/kg）和克林霉素（70 mg/kg）每6小时皮下注射1次，共28天。治疗后，在23只对照兔中的22只、接受头孢唑林（5 mg/kg）治疗的22只兔中的12只、接受头孢唑林（15 mg/kg）治疗的23只兔中的12只以及接受克林霉素治疗的20只兔中的2只的骨培养物中发现了金黄色葡萄球菌。在一组已感染3至4周的兔中注射头孢唑林或克林霉素30分钟后，测量血清、未感染骨和感染骨中的药物浓度。克林霉素在感染骨和未感染骨中的浓度最高。研究结果表明，在实验模型中，克林霉素在清除感染骨中的金黄色葡萄球菌方面优于头孢唑林。
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