Kosoy Olga I, Lambert Amy J, Hawkinson Dana J, Pastula Daniel M, Goldsmith Cynthia S, Hunt D Charles, Staples J Erin
Emerg Infect Dis. 2015 May;21(5):760-4. doi: 10.3201/eid2105.150150.
A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus.
一名来自美国堪萨斯州东部的既往健康男子，于春末因蜱叮咬史、发热和疲劳而寻求医疗护理。该患者出现血小板减少和白细胞减少，并因疑似蜱传疾病接受了强力霉素治疗。他的病情没有改善。多器官功能衰竭出现，发病11天后因心肺骤停死亡。已知蜱传病原体的分子和血清学检测结果均为阴性。然而，通过蚀斑减少中和试验检测针对哈特兰病毒抗体的标本结果显示存在另一种病毒。下一代测序和系统发育分析将该病毒鉴定为托高土病毒属的一个新成员。
