Galar-Martínez M, García-Medina S, Gómez-Olivan L M, Pérez-Coyotl I, Mendoza-Monroy D J, Arrazola-Morgain R E
Departamento de Farmacia, Laboratorio de Toxicología Acuática, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
Unidad Analítica de la Unidad de Farmacología Clínica, Facultad de Medicina - UNAM, Nezahualcóyotl, Edo de México.
Environ Toxicol. 2016 Sep;31(9):1035-43. doi: 10.1002/tox.22113. Epub 2015 Apr 21.
The nonsteroidal anti-inflammatory drug ketorolac is extensively used in the treatment of acute postoperative pain. This pharmaceutical has been found at concentrations of 0.2-60 µg/L in diverse water bodies around the world; however, its effects on aquatic organisms remain unknown. The present study, evaluated the oxidative stress and genotoxicity induced by sublethal concentrations of ketorolac (1 and 60 µg/L) on liver, brain, and blood of the common carp Cyprinus carpio. This toxicant induced oxidative damage (increased lipid peroxidation, hydroperoxide content, and protein carbonyl content) as well as changes in antioxidant status (superoxide dismutase, catalase, and glutathione peroxidase activity) in liver and brain of carp. In blood, ketorolac increased the frequency of micronuclei and is therefore genotoxic for the test species. The effects observed were time and concentration dependent. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1035-1043, 2016.
非甾体抗炎药酮咯酸被广泛用于治疗急性术后疼痛。在世界各地不同的水体中已发现这种药物的浓度为0.2 - 60微克/升；然而，其对水生生物的影响仍然未知。本研究评估了亚致死浓度的酮咯酸（1和60微克/升）对鲤鱼肝脏、大脑和血液诱导的氧化应激和遗传毒性。这种毒物在鲤鱼的肝脏和大脑中诱导了氧化损伤（脂质过氧化增加、氢过氧化物含量和蛋白质羰基含量增加）以及抗氧化状态的变化（超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性）。在血液中，酮咯酸增加了微核频率，因此对受试物种具有遗传毒性。观察到的影响具有时间和浓度依赖性。© 2015威利期刊公司。环境毒理学31: 1035 - 1043, 2016。
