Crow T J, Ball J, Bloom S R, Brown R, Bruton C J, Colter N, Frith C D, Johnstone E C, Owens D G, Roberts G W
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow, England.
Arch Gen Psychiatry. 1989 Dec;46(12):1145-50. doi: 10.1001/archpsyc.1989.01810120087013.
Schizophrenia is associated with structural changes (eg, a mild degree of ventricular enlargement) in the brain, although whether these precede onset of illness or progress with episodes is not established. In a postmortem study, we find that ventricular enlargement affects the posterior and particularly the temporal horn of the lateral cerebral ventricle. By comparison with controls and with patients suffering from Alzheimer-type dementia (in which there is also temporal horn enlargement), the change is highly significantly selective to the left hemisphere. This deviation was not accompanied by an increase in glial cell number (examined chemically by assay of diazepam-binding inhibitor immunoreactivity and microscopically by density of staining with the Holzer technique). The findings are consistent with the view that schizophrenia is a disorder of the genetic mechanisms that control the development of cerebral asymmetry.
精神分裂症与大脑结构变化（如轻度脑室扩大）有关，尽管这些变化是在疾病发作之前出现还是随发作进展尚未确定。在一项尸检研究中，我们发现脑室扩大影响大脑侧脑室的后部，尤其是颞角。与对照组以及患有阿尔茨海默型痴呆（也有颞角扩大）的患者相比，这种变化对左半球具有高度显著的选择性。这种偏差并未伴随胶质细胞数量的增加（通过地西泮结合抑制剂免疫反应性测定进行化学检测，以及通过霍尔泽技术染色密度进行显微镜检查）。这些发现与精神分裂症是一种控制大脑不对称发育的遗传机制紊乱的观点一致。
