Brown R, Colter N, Corsellis J A, Crow T J, Frith C D, Jagoe R, Johnstone E C, Marsh L
Arch Gen Psychiatry. 1986 Jan;43(1):36-42. doi: 10.1001/archpsyc.1986.01800010038005.
The brains of 232 patients with a case-note diagnosis of schizophrenia or affective disorder who died in one mental hospital over a period of 22 years were weighed, and were assessed in a coronal section at the level of the interventricular foramina. From this sample were eliminated the brains of patients whose illnesses did not meet the Washington University criteria for a diagnosis of definite schizophrenia or primary affective disorder and those brains that showed significant histopathologic evidence of Alzheimer's-type change or cerebrovascular disease. This left a sample of 41 patients with schizophrenia and 29 patients with affective disorder. With age, sex, and year of birth controlled for, the brains of the patients with schizophrenia were 6% lighter, had lateral ventricles that were larger in the anterior (by 19%), and particularly in the temporal, (by 97%) horn cross section, and had significantly thinner parahippocampal cortices (by 11%). The findings provide postmortem confirmation of reports of ventricular enlargement in radiological studies and suggest that such enlargement is associated with tissue loss in the temporal lobe. The changes in schizophrenia were of a lesser degree than those seen in a sample of brains of patients with Alzheimer's-type dementia and Huntington's chorea.
对一家精神病院里232名病历诊断为精神分裂症或情感障碍且在22年期间死亡的患者的大脑进行称重，并在室间孔水平的冠状切面进行评估。从这个样本中排除了疾病不符合华盛顿大学明确精神分裂症或原发性情感障碍诊断标准的患者的大脑，以及那些显示出阿尔茨海默病型改变或脑血管疾病显著组织病理学证据的大脑。这留下了41名精神分裂症患者和29名情感障碍患者的样本。在控制了年龄、性别和出生年份后，精神分裂症患者的大脑轻6%，侧脑室前角横截面更大（大19%），特别是颞角横截面更大（大97%），海马旁皮质明显更薄（薄11%）。这些发现为放射学研究中关于脑室扩大的报告提供了尸检证实，并表明这种扩大与颞叶组织损失有关。精神分裂症中的变化程度低于阿尔茨海默病型痴呆和亨廷顿舞蹈症患者大脑样本中的变化程度。
