Murata Toshihiro, Selenge Erdenechimeg, Oikawa Saki, Ageishi Keita, Batkhuu Javzan, Sasaki Kenroh, Yoshizaki Fumihiko
Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan,
J Nat Med. 2015 Oct;69(4):471-8. doi: 10.1007/s11418-015-0908-6. Epub 2015 Apr 22.
A diterpenoid diglucoside (12,19-di-O-β-D-glucopyranosyl-11-hydroxyabieta-8,11,13-triene-19-one), isoscutellarein 7-O-[β-D-xylopyranosyl-(1→2)]-β-D-glucopyranoside, isoscutellarein 7-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside, hypolaetin 7-O-[6″-O-(p-E-coumaroyl)]-β-D-glucopyranoside, hypolaetin 7-O-[6″-O-(E-caffeoyl)]-β-D-glucopyranoside, and 15 known compounds were isolated from aerial parts of the Mongolian medicinal plant Caryopteris mongolica. The cholinesterase-inhibitory activities of the constituents were estimated. The abietane diterpenoids (12-O-demethylcryptojaponol and 6α-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum.
从蒙古药用植物蒙古莸的地上部分分离得到一种二萜二糖苷（12,19-二-O-β-D-吡喃葡萄糖基-11-羟基枞-8,11,13-三烯-19-酮）、异野黄芩素7-O-[β-D-吡喃木糖基-(1→2)]-β-D-吡喃葡萄糖苷、异野黄芩素7-O-[α-L-鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷、异槲皮素7-O-[6″-O-(对-E-香豆酰基)]-β-D-吡喃葡萄糖苷、异槲皮素7-O-[6″-O-(E-咖啡酰基)]-β-D-吡喃葡萄糖苷以及15种已知化合物。对这些成分的胆碱酯酶抑制活性进行了评估。枞烷型二萜（12-O-去甲基隐日本醇和6α-羟基去甲基隐日本醇）对人红细胞和电鳗的乙酰胆碱酯酶以及马血清的丁酰胆碱酯酶显示出较强的抑制活性。
