Singla Nidhi, Arora Sunita, Goel Poonam, Chander Jagdish, Huria Anju
Departments of Microbiology, Government Medical College Hospital, Chandigarh, India.
Departments of Obstetrics & Gynaecology, Government Medical College Hospital, Chandigarh, India.
Asian Pac J Trop Med. 2015 Mar;8(3):206-8. doi: 10.1016/S1995-7645(14)60316-3.
To keep the level of awareness high as far as incidence of dengue among pregnant women is concerned.
A total of 300 blood samples of patients with fever in pregnancy were received in the Department of Microbiology to rule out dengue infection (January 2011 to December 2012). The samples were put up for presence of dengue IgM antibodies and NS1Ag by ELISA. The patients who turned out to be positive for dengue serology were retrospectively analysed with respect to patient's age, gestational age, clinical presentation, complications, platelet counts and maternal as well as foetal outcomes.
Out of 300 females tested, 22 (7.3%) were found positive for dengue infection during the said time period. Out of them 9 were positive for IgM antibodies against dengue and 10 were found to be positive for NS1Ag, while 3 were positive for both IgM antibody and NS1Ag. Five patients presented with dengue in first trimester, 9 in second trimester and 8 in third trimester. Two patients had coinfections. Patient with coinfection of dengue with malaria had intrauterine death of fetus at 37 weeks while the second one having dengue with typhoid had a preterm vaginal delivery at 35 weeks.
Establishing diagnosis of dengue infection in pregnancy is important for effective management by the obstetricians particularly the mode of delivery due to the potential risk of hemorrhage for both the mother and the newborn. Co-infections seen in endemic areas may be more common than usually reported.
就孕妇登革热发病率而言，保持较高的认知水平。
微生物科共接收了300份孕期发热患者的血样，以排除登革热感染（2011年1月至2012年12月）。通过酶联免疫吸附测定法检测血样中登革热IgM抗体和NS1抗原的存在情况。对登革热血清学检测呈阳性的患者，就其年龄、孕周、临床表现、并发症、血小板计数以及母婴结局进行回顾性分析。
在接受检测的300名女性中，有22名（7.3%）在上述时间段内被发现登革热感染呈阳性。其中9名登革热IgM抗体呈阳性，10名NS1抗原呈阳性，3名IgM抗体和NS1抗原均呈阳性。5名患者在孕早期出现登革热，9名在孕中期，8名在孕晚期。2名患者存在合并感染。一名登革热与疟疾合并感染的患者在37周时胎儿宫内死亡，另一名登革热与伤寒合并感染的患者在35周时早产。
对于产科医生进行有效管理而言，尤其是考虑到母亲和新生儿出血的潜在风险，确定孕期登革热感染的诊断很重要。在流行地区发现的合并感染可能比通常报道的更为常见。
