孕期登革热和疟疾感染：一家三级护理医院的母婴及新生儿结局
Dengue and malaria infections in pregnancy : Maternal, fetal and neonatal outcomes at a tertiary care hospital.
作者信息
Mubashir Mujtaba, Ahmed Kaleem S, Mubashir Hadika, Quddusi Ayesha, Farooq Ayesha, Ahmed Sheikh Irfan, Jamil Bushra, Qureshi Rahat
机构信息
Aga Khan University Medical College, Karachi, Pakistan.
Department of Obstetrics and Gynaecology, Aga Khan University, Karachi, Pakistan.
出版信息
Wien Klin Wochenschr. 2020 Apr;132(7-8):188-196. doi: 10.1007/s00508-019-01606-8. Epub 2020 Jan 29.
BACKGROUND
Malaria and dengue cause major morbidity in developing nations and are more severe in pregnancy. Maternal, fetal, and neonatal outcomes in pregnant patients infected with dengue or malaria were studied.
METHODS
The medical records of pregnant women admitted with either dengue or malaria infections from 2011-2015 to this hospital were reviewed. Clinical outcomes and laboratory tests were examined.
RESULTS
Of 85 women, 56%, 21%, and 22% had contracted dengue, malaria, and multiple infections, respectively. Pregnant women who had contracted dengue fever alone were more likely to present to the hospital at an earlier gestational age (24 weeks, p = 0.03). Women with multiple infections, were more likely to deliver earlier (30 weeks, p < 0.01). Women with malaria were more likely to have low birth weight deliveries (mean birth weight 2394 g, p = 0.03). The incidence of in-hospital deaths among the cohort was 7%.
CONCLUSION
It is imperative to develop guidelines to screen for and diagnose dengue and malaria in pregnancy.
背景
疟疾和登革热在发展中国家导致严重发病，且在孕期病情更为严重。对感染登革热或疟疾的孕妇的孕产妇、胎儿及新生儿结局进行了研究。
方法
回顾了2011年至2015年期间因登革热或疟疾感染入住本院的孕妇的病历。检查了临床结局和实验室检查结果。
结果
85名女性中，分别有56%、21%和22%感染了登革热、疟疾和多重感染。仅感染登革热的孕妇更有可能在孕早期（24周）入院（p = 0.03）。多重感染的女性更有可能早产（30周，p < 0.01）。感染疟疾的女性更有可能分娩低体重儿（平均出生体重2394克，p = 0.03）。该队列中的院内死亡率为7%。
结论
制定孕期登革热和疟疾筛查及诊断指南势在必行。
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