孕期登革热感染症状及病程的回顾性分析。
A retrospective analysis of the symptoms and course of dengue infection during pregnancy.
作者信息
Agarwal Kavita, Malik Sunita, Mittal Pratima
机构信息
Department of Obstetrics and Gynaecology, Safdarjung Hospital, New Delhi, India.
出版信息
Int J Gynaecol Obstet. 2017 Oct;139(1):4-8. doi: 10.1002/ijgo.12245. Epub 2017 Jul 11.
OBJECTIVE
To assess outcomes among pregnant women diagnosed with dengue infection.
METHODS
In a retrospective study, the medical records of all pregnant women with dengue infection admitted to Safdarjung Hospital, New Delhi, India, from July to December 2015 were reviewed. Maternal and fetal outcomes were compared by pregnancy length and stage of disease at diagnosis.
RESULTS
Overall, 62 pregnant women with dengue infection were identified. Of these, 56 (90%) tested negative for nonstructural protein 1 (NS1) antigen, indicating a later stage of disease. Maternal near miss and mortality were significantly more common among women with DHF or DSS than among those with dengue fever (P<0.001). Spontaneous abortion occurred for four of six women diagnosed in the first trimester, and one of two women diagnosed in the second trimester. Among 22 women diagnosed at 26-36 weeks, 9 (41%) delivered preterm. There was one case of stillbirth at 37 weeks and no cases of neonatal death.
CONCLUSION
Women diagnosed with dengue fever had far better outcomes than did those with DHF or DSS.
目的
评估被诊断为登革热感染的孕妇的结局。
方法
在一项回顾性研究中，对2015年7月至12月入住印度新德里萨夫达容医院的所有登革热感染孕妇的病历进行了审查。根据诊断时的孕周和疾病阶段比较母婴结局。
结果
总体而言，共识别出62例登革热感染孕妇。其中，56例（90%）非结构蛋白1（NS1）抗原检测呈阴性，表明疾病处于后期。登革出血热（DHF）或登革休克综合征（DSS）患者中孕产妇严重并发症和死亡明显比登革热患者更常见（P<0.001）。孕早期诊断的6名女性中有4名发生自然流产，孕中期诊断的2名女性中有1名发生自然流产。在26至36周诊断的22名女性中，9名（41%）早产。有1例37周死产，无新生儿死亡病例。
结论
被诊断为登革热的女性结局远好于登革出血热或登革休克综合征患者。
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