Bouchoucha Michel, Fysekidis Marinos, Julia Chantal, Airinei Gheorghe, Catheline Jean-Marc, Reach Gérard, Benamouzig Robert
Physiology Department, Université René Descartes, Paris V, Paris, France.
Gastroenterology Department, Avicenne Hospital, Bobigny, France.
Obes Surg. 2015 Nov;25(11):2143-52. doi: 10.1007/s11695-015-1679-6.
Obesity is frequently associated to many functional gastrointestinal disorders. The aim of the present study was to assess the prevalence of functional gastrointestinal disorders in obese patients, according to their body mass index and their recruitment source.
Five hundred ninety-six obese patients (body mass index (BMI) > 30) filled out a standard questionnaire in order to evaluate the presence of functional gastrointestinal disorders. They were divided into four groups according to the Rome III criteria and their BMI: OF, obese patients from functional gastrointestinal disorder (FGID) enrollment; OO, obese patients from obesity management enrollment; MF, morbid obesity patients from FGID enrollment; and MO, morbid obesity patients from obesity management enrollment. Data analysis was performed using multivariate logistic regression.
Out of the 596 obese patients included in the present study, 183 (33 %) were complaining of FGIDs, while 413 (67 %) were consulting for obesity management. Compared to the OF group, the OO patients had a higher prevalence of females (P = 0.008) and a younger age (P < 0.001). Clinically, they reported a lower incidence of regurgitation (P = 0.044), of chest pain (P = 0.004), of irritable bowel syndrome (IBS; P = 0.035), and of functional diarrhea (P = 0.030). Compared to the MF group, the MO patients had an older age (P = 0.001), a higher BMI (P = 0.013), and clinically by a high frequency of functional dyspepsia (P = 0.006). There were symptoms that had similar prevalence in all groups (OF, OO, MF, MO) such as epigastric pain, postprandial distress, constipation, diarrhea, bloating, abdominal pain soiling, or nonspecific anorectal disorders.
This study has shown that the recruitment source accounted for marked and specific differences in the prevalence of functional gastrointestinal disorders in obesity and morbid obesity. Symptoms with similar prevalence in all groups should be systematically detected in all patients.
肥胖常与多种功能性胃肠疾病相关。本研究旨在根据肥胖患者的体重指数及其招募来源，评估功能性胃肠疾病的患病率。
596名肥胖患者（体重指数（BMI）>30）填写了一份标准问卷，以评估功能性胃肠疾病的存在情况。根据罗马III标准及其BMI，他们被分为四组：OF，来自功能性胃肠疾病（FGID）登记的肥胖患者；OO，来自肥胖管理登记的肥胖患者；MF，来自FGID登记的病态肥胖患者；MO，来自肥胖管理登记的病态肥胖患者。使用多因素逻辑回归进行数据分析。
在本研究纳入的596名肥胖患者中，183名（33%）主诉患有功能性胃肠疾病，而413名（67%）因肥胖管理前来咨询。与OF组相比，OO组女性患病率更高（P = 0.008）且年龄更小（P < 0.001）。临床上，他们报告反流发生率较低（P = 0.044）、胸痛发生率较低（P = 0.004）、肠易激综合征（IBS；P = 0.035）和功能性腹泻发生率较低（P = 0.030）。与MF组相比，MO组年龄更大（P = 0.001）、BMI更高（P = 0.013），临床上功能性消化不良发生率较高（P = 0.006）。所有组（OF、OO、MF、MO）中某些症状的患病率相似，如胃痛、餐后不适、便秘、腹泻、腹胀、腹痛伴排便、或非特异性肛肠疾病。
本研究表明，招募来源在肥胖和病态肥胖患者功能性胃肠疾病患病率方面存在显著且特定的差异。应在所有患者中系统检测所有组中患病率相似的症状。
