Postgraduate Program in Natural and Synthetic Products Bioactive/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Oxid Med Cell Longev. 2021 Jul 27;2021:3260789. doi: 10.1155/2021/3260789. eCollection 2021.
The consumption of hypercaloric diets is related to the development of obesity, favoring the etiology of gastrointestinal disorders. In this context, (SP), some blue-green algae with antioxidant action, appears as a potential therapeutic alternative to prevent obesity and associated intestinal disorders. Thus, the present study is aimed at evaluating the deleterious effects of the hypercaloric diet on the contractile and relaxing reactivity of the ileum of rats, as well as the possible preventive mechanisms of dietary supplementation with SP. Wistar rats were divided into three groups: fed a standard diet (SD), a hypercaloric diet (HCD), and/or supplemented with 25 mg/kg SP (HCD + SP25) for 8 weeks. The hypercaloric diet was effective in promoting obesity in rats, as well as decreasing potency and ileal relaxing and contractile efficacy. In contrast, dietary supplementation with SP was able to prevent some of the parameters of experimental obesity. In addition, SP prevented the reduction of intestinal reactivity, possibly due to a positive modulation of voltage-gated calcium channels (Ca) and negative regulation of muscarinic receptors (M3). Thus, food supplementation with becomes a promising alternative in the prevention of gastrointestinal diseases induced and/or aggravated by obesity.
高热量饮食的摄入与肥胖的发生有关，有利于胃肠道疾病的发病机制。在这种情况下，（SP），一些具有抗氧化作用的蓝绿藻，作为预防肥胖和相关肠道疾病的潜在治疗选择出现。因此，本研究旨在评估高热量饮食对大鼠回肠收缩和舒张反应的有害影响，以及用 SP 进行饮食补充的可能预防机制。Wistar 大鼠分为三组：标准饮食（SD）组、高热量饮食（HCD）组和/或补充 25mg/kg SP（HCD+SP25）8 周。高热量饮食可有效促进大鼠肥胖，并降低回肠收缩和舒张的效能。相比之下，SP 的饮食补充能够预防实验性肥胖的一些参数。此外，SP 防止了肠道反应性的降低，这可能是由于电压门控钙通道（Ca）的正向调节和毒蕈碱受体（M3）的负调节。因此，用 SP 进行食物补充成为预防肥胖引起和/或加重的胃肠道疾病的有希望的选择。
