TKM-100802和恢复期血浆在美国2例埃博拉病毒病患者中的应用
The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States.
作者信息
Kraft Colleen S, Hewlett Angela L, Koepsell Scott, Winkler Anne M, Kratochvil Christopher J, Larson LuAnn, Varkey Jay B, Mehta Aneesh K, Lyon G Marshall, Friedman-Moraco Rachel J, Marconi Vincent C, Hill Charles E, Sullivan James N, Johnson Daniel W, Lisco Steven J, Mulligan Mark J, Uyeki Timothy M, McElroy Anita K, Sealy Tara, Campbell Shelley, Spiropoulou Christina, Ströher Ute, Crozier Ian, Sacra Richard, Connor Michael J, Sueblinvong Viranuj, Franch Harold A, Smith Philip W, Ribner Bruce S
机构信息
Department of Pathology and Laboratory Medicine Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
Division of Infectious Diseases, Department of Internal Medicine.
出版信息
Clin Infect Dis. 2015 Aug 15;61(4):496-502. doi: 10.1093/cid/civ334. Epub 2015 Apr 22.
BACKGROUND
The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.
METHODS
We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma.
RESULTS
While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.
CONCLUSIONS
It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
背景
当前西非埃博拉病毒病（EVD）疫情导致多名患者被转运至其他国家接受临床治疗。
方法
我们报告了两名从西非转运至美国接受埃博拉病毒病治疗的患者。两名患者均接受了积极的支持性治疗措施，以及一种试验性治疗药物（TKM - 100802）和康复期血浆治疗。
结果
其中一名患者病情危急，出现多器官功能衰竭，需要机械通气和肾脏替代治疗，但两名患者目前均已康复，且无严重的长期后遗症。
结论
尚不清楚实验性药物和康复期血浆在这些患者康复过程中发挥了何种作用。需要进行前瞻性临床试验，以明确试验性治疗在埃博拉病毒病患者治疗中的作用。
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