铜（I）催化的 N-Boc-亚胺的不对称频哪醇硼基加成反应，使用手性亚砜-膦配体。
Copper(I)-Catalyzed Asymmetric Pinacolboryl Addition of N-Boc-imines Using a Chiral Sulfoxide-Phosphine Ligand.
机构信息
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Org Lett. 2015 May 15;17(10):2420-3. doi: 10.1021/acs.orglett.5b00934. Epub 2015 Apr 23.
PMID:25906191
Abstract
Highly efficient and enantioselective copper(I)-catalyzed pinacolboryl addition of N-Boc-imines is reported. By using a single chiral sulfoxide-(dialkyl)phosphine (SOP) ligand, both enantiomeric isomers of α-amino boronic esters were obtained through an achiral counteranion switch.
摘要
报道了高效和对映选择性的铜（I）催化 N-Boc-亚胺的频哪醇硼基加成反应。通过使用单一手性亚砜-（二烷基）膦（SOP）配体，通过手性抗衡阴离子的切换，得到了α-氨基硼酸酯的两种对映异构体。
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