Haglund Margaret, Ang Alfonso, Mooney Larissa, Gonzales Rachel, Chudzynski Joy, Cooper Christopher B, Dolezal Brett A, Gitlin Michael, Rawson Richard A
Adult Division of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, California.
Integrated Substance Abuse Programs, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, California.
Am J Addict. 2015 Apr;24(3):246-251. doi: 10.1111/ajad.12175.
This paper expands on a study investigating depression outcomes in response to an 8-week exercise intervention among methamphetamine (MA) dependent individuals in early recovery.
A total of 135 MA-dependent individuals enrolled in residential treatment were randomly assigned to either a structured exercise intervention or a structured health education control group. Both groups were similar in format: 60-minute sessions, offered three times a week over an 8-week study period.
Results showed that at the 8-week trial endpoint, participants randomized to the exercise intervention showed significantly greater reduction in depression symptom scores than participants randomized to the health education group, and that participants who attended the greatest number of exercise sessions derived the greatest benefit. This paper further analyzes study data to uncover individual predictors of depression response to exercise and finds that among participants randomized to exercise treatment, individuals with the most severe medical, psychiatric, and addiction disease burden at baseline showed the most significant improvement in depressive symptoms by study endpoint.
Our findings suggest that exercise in moderate dose is effective at treating depressive symptoms in individuals in early recovery from addiction, and furthermore, that treatment with exercise appears to be particularly beneficial to individuals who suffer from severe medical, psychiatric, and addictive disorders.
本文是一项研究的拓展，该研究调查了甲基苯丙胺（MA）依赖个体在早期康复阶段接受为期8周的运动干预后的抑郁状况。
共有135名入住住院治疗机构的MA依赖个体被随机分配至结构化运动干预组或结构化健康教育对照组。两组的形式相似：每次60分钟课程，在为期8周的研究期间每周进行三次。
结果显示，在为期8周的试验终点，随机分配至运动干预组的参与者在抑郁症状评分上的降低幅度显著大于随机分配至健康教育组的参与者，且参加运动课程次数最多的参与者受益最大。本文进一步分析研究数据以揭示运动对抑郁反应的个体预测因素，发现在随机分配至运动治疗组的参与者中，基线时患有最严重的医学、精神和成瘾疾病负担的个体在研究终点时抑郁症状改善最为显著。
我们的研究结果表明，中等剂量的运动对于成瘾早期康复个体的抑郁症状治疗有效，此外，运动治疗似乎对患有严重医学、精神和成瘾性疾病的个体特别有益。
